Enhanced Antitumor Activity with Combining Effect of mTOR Inhibition and Microtubule Stabilization in Hepatocellular Carcinoma

Mammalian target of rapamycin (mTOR) and the microtubules are shown to be potential targets for treating hepatocellular carcinoma (HCC). PI3K/Akt/mTOR activation is associated with resistance to microtubule inhibitors. Here, we evaluated the antitumor activity by cotargeting of the mTOR (using allos...

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Detalles Bibliográficos
Autores principales: Zhou, Qian, Wong, Chi Hang, Lau, Cecilia Pik Yuk, Hui, Connie Wun Chun, Lui, Vivian Wai Yan, Chan, Stephen Lam, Yeo, Winnie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590758/
https://www.ncbi.nlm.nih.gov/pubmed/23509629
http://dx.doi.org/10.1155/2013/103830

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590758/
https://www.ncbi.nlm.nih.gov/pubmed/23509629
http://dx.doi.org/10.1155/2013/103830

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