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Adding 11C-acetate to 18F-FDG at PET Examination Has an Incremental Value in the Diagnosis of Hepatocellular Carcinoma
Objective: The sensitivity of FDG at PET examination of Hepatocellular Carcinoma (HCC) is restricted. In a few studies, all done in Oriental patients, PET-examination with (11)C-acetate has shown a higher accuracy than with FDG. In the current study, the uptake of (11)C-acetate has been compared wit...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Galenos Publishing
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590959/ https://www.ncbi.nlm.nih.gov/pubmed/23487415 http://dx.doi.org/10.4274/Mirt.87 |
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author | Larsson, Patricia Arvidsson, Dag Björnstedt, Mikael Isaksson, Bengt Jersenius, Ulf Motarjemi, Hooman Jacobsson, Hans |
author_facet | Larsson, Patricia Arvidsson, Dag Björnstedt, Mikael Isaksson, Bengt Jersenius, Ulf Motarjemi, Hooman Jacobsson, Hans |
author_sort | Larsson, Patricia |
collection | PubMed |
description | Objective: The sensitivity of FDG at PET examination of Hepatocellular Carcinoma (HCC) is restricted. In a few studies, all done in Oriental patients, PET-examination with (11)C-acetate has shown a higher accuracy than with FDG. In the current study, the uptake of (11)C-acetate has been compared with the uptake of FDG in the primary HCC in a cohort of Occidental patients. Material and Methods: 44 patients underwent PET-examination with both tracers with a mean of 9 days between the examinations. 26 patients had a microscopical diagnosis and 18 were diagnosed with multimodal radiological methods. At least one relevant radiological examination was available for comparison. Results: At visual evaluation, 13 of the HCC’s were positive at PET-examination using FDG and 34 were positive using (11)C-acetate (p<0.001). Median tumor SUV(mean) of (11)C-acetate was 4.7 and of FDG was 1.9 (p<0.001). There was also a higher uptake of (11)C-acetate by the surrounding liver tissue than of FDG. Median liver SUV(mean) of [u]11[/u]C-acetate was 3.2 and of FDG it was 1.7 (p<0.001). This corresponded to a median tumour/liver tissue ratio for (11)C-acetate of 1.4 and for FDG of 1.0 (p<0.05). Previous reports of a negative correlation between the uptake of the tracers were weakly supported. In 4 large tumors some portions being hot using one of the tracers were cold using the other tracer and vice versa. Conclusion: Adding registration with (11)C-acetate to registration with FDG at PET-examination has an incremental value in the diagnosis of HCC. A higher tumor uptake of (11)C-acetate cannot be taken full advantage of because of a higher uptake also by the surrounding liver tissue. Conflict of interest:None declared. |
format | Online Article Text |
id | pubmed-3590959 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Galenos Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-35909592013-03-13 Adding 11C-acetate to 18F-FDG at PET Examination Has an Incremental Value in the Diagnosis of Hepatocellular Carcinoma Larsson, Patricia Arvidsson, Dag Björnstedt, Mikael Isaksson, Bengt Jersenius, Ulf Motarjemi, Hooman Jacobsson, Hans Mol Imaging Radionucl Ther Original Article Objective: The sensitivity of FDG at PET examination of Hepatocellular Carcinoma (HCC) is restricted. In a few studies, all done in Oriental patients, PET-examination with (11)C-acetate has shown a higher accuracy than with FDG. In the current study, the uptake of (11)C-acetate has been compared with the uptake of FDG in the primary HCC in a cohort of Occidental patients. Material and Methods: 44 patients underwent PET-examination with both tracers with a mean of 9 days between the examinations. 26 patients had a microscopical diagnosis and 18 were diagnosed with multimodal radiological methods. At least one relevant radiological examination was available for comparison. Results: At visual evaluation, 13 of the HCC’s were positive at PET-examination using FDG and 34 were positive using (11)C-acetate (p<0.001). Median tumor SUV(mean) of (11)C-acetate was 4.7 and of FDG was 1.9 (p<0.001). There was also a higher uptake of (11)C-acetate by the surrounding liver tissue than of FDG. Median liver SUV(mean) of [u]11[/u]C-acetate was 3.2 and of FDG it was 1.7 (p<0.001). This corresponded to a median tumour/liver tissue ratio for (11)C-acetate of 1.4 and for FDG of 1.0 (p<0.05). Previous reports of a negative correlation between the uptake of the tracers were weakly supported. In 4 large tumors some portions being hot using one of the tracers were cold using the other tracer and vice versa. Conclusion: Adding registration with (11)C-acetate to registration with FDG at PET-examination has an incremental value in the diagnosis of HCC. A higher tumor uptake of (11)C-acetate cannot be taken full advantage of because of a higher uptake also by the surrounding liver tissue. Conflict of interest:None declared. Galenos Publishing 2012-04 2012-04-01 /pmc/articles/PMC3590959/ /pubmed/23487415 http://dx.doi.org/10.4274/Mirt.87 Text en © Molecular Imaging and Radionuclide Therapy, Published by Galenos Publishing. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Larsson, Patricia Arvidsson, Dag Björnstedt, Mikael Isaksson, Bengt Jersenius, Ulf Motarjemi, Hooman Jacobsson, Hans Adding 11C-acetate to 18F-FDG at PET Examination Has an Incremental Value in the Diagnosis of Hepatocellular Carcinoma |
title | Adding 11C-acetate to 18F-FDG at PET Examination Has an Incremental Value in the Diagnosis of Hepatocellular Carcinoma |
title_full | Adding 11C-acetate to 18F-FDG at PET Examination Has an Incremental Value in the Diagnosis of Hepatocellular Carcinoma |
title_fullStr | Adding 11C-acetate to 18F-FDG at PET Examination Has an Incremental Value in the Diagnosis of Hepatocellular Carcinoma |
title_full_unstemmed | Adding 11C-acetate to 18F-FDG at PET Examination Has an Incremental Value in the Diagnosis of Hepatocellular Carcinoma |
title_short | Adding 11C-acetate to 18F-FDG at PET Examination Has an Incremental Value in the Diagnosis of Hepatocellular Carcinoma |
title_sort | adding 11c-acetate to 18f-fdg at pet examination has an incremental value in the diagnosis of hepatocellular carcinoma |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590959/ https://www.ncbi.nlm.nih.gov/pubmed/23487415 http://dx.doi.org/10.4274/Mirt.87 |
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