Cargando…

Demonstration of Adaptive Functional Differences Seen in Kidneys Accompanying a Nonfunctioning/Hypofunctioning Partner, using Camera Based Tc 99m MAG3 Clearance Measurement Technique

Objective: The aim of this study was to demonstrate the functional compensation that occurs in kidneys which accompany a partner with total or partial loss of renal functioning mass, using camera-based Tc 99m MAG3 clearance technique. Material and Methods: Eighty five patients (43M, 42F, age: 44.8±1...

Descripción completa

Detalles Bibliográficos
Autores principales: Akkaş, Burcu Esen, Vural, Gülin Uçmak, Akdemir, Ümit Özgür, Karabacak, Neşe İlgin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Galenos Publishing 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590969/
https://www.ncbi.nlm.nih.gov/pubmed/23486848
http://dx.doi.org/10.4274/Mirt.309
_version_ 1782261955105390592
author Akkaş, Burcu Esen
Vural, Gülin Uçmak
Akdemir, Ümit Özgür
Karabacak, Neşe İlgin
author_facet Akkaş, Burcu Esen
Vural, Gülin Uçmak
Akdemir, Ümit Özgür
Karabacak, Neşe İlgin
author_sort Akkaş, Burcu Esen
collection PubMed
description Objective: The aim of this study was to demonstrate the functional compensation that occurs in kidneys which accompany a partner with total or partial loss of renal functioning mass, using camera-based Tc 99m MAG3 clearance technique. Material and Methods: Eighty five patients (43M, 42F, age: 44.8±12.6, range: 18-77 years) with normal serum creatinine levels and normal (<Grade 1) Tc 99m MAG3 renogram curves were enrolled for this retrospective study. Patients were grouped as having; group 1: solitary normal kidney (unilateral atrophied/agenetic) (n=23), group 2: normal kidney with contralateral hypoplasic/hypofunctioning kidney (split renal function<30%), (n=24), group 3: bilateral normal kidneys (n=38). The measured camera based Tc 99m MAG3 clearances of normal kidneys in each group were compared. Results: Total Tc 99m MAG3 clearances (mL/min/1.73m2) were significantly lower in group 1 and group 2 compared to group 3 (281.5±46, 260.5±61.7 and 316.1±84, respectively). Highest isolated Tc 99m MAG3 clearances among normal functioning kidneys were observed in group 1 (281.5±45.6) followed by group 2 (204.4±55) and group 3 (157.5±44). Moderate negative correlation was detected between the Tc99m MAG3 clearances of normal kidneys and contralateral renal function (r=-0.5, p<0.001). Conclusion: Normal kidneys can compensate for the loss of contralateral kidney function via increasing their clearances, which seems to be dependent on the residual function of their partner. Camera based Tc 99m MAG3 clearance measurement is an objective method to demonstrate compensatory differences in renal function seen between kidneys with contralateral normofunctioning, hypofunctioning and nonfunctioning partner. Conflict of interest:None declared.
format Online
Article
Text
id pubmed-3590969
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Galenos Publishing
record_format MEDLINE/PubMed
spelling pubmed-35909692013-03-13 Demonstration of Adaptive Functional Differences Seen in Kidneys Accompanying a Nonfunctioning/Hypofunctioning Partner, using Camera Based Tc 99m MAG3 Clearance Measurement Technique Akkaş, Burcu Esen Vural, Gülin Uçmak Akdemir, Ümit Özgür Karabacak, Neşe İlgin Mol Imaging Radionucl Ther Original Article Objective: The aim of this study was to demonstrate the functional compensation that occurs in kidneys which accompany a partner with total or partial loss of renal functioning mass, using camera-based Tc 99m MAG3 clearance technique. Material and Methods: Eighty five patients (43M, 42F, age: 44.8±12.6, range: 18-77 years) with normal serum creatinine levels and normal (<Grade 1) Tc 99m MAG3 renogram curves were enrolled for this retrospective study. Patients were grouped as having; group 1: solitary normal kidney (unilateral atrophied/agenetic) (n=23), group 2: normal kidney with contralateral hypoplasic/hypofunctioning kidney (split renal function<30%), (n=24), group 3: bilateral normal kidneys (n=38). The measured camera based Tc 99m MAG3 clearances of normal kidneys in each group were compared. Results: Total Tc 99m MAG3 clearances (mL/min/1.73m2) were significantly lower in group 1 and group 2 compared to group 3 (281.5±46, 260.5±61.7 and 316.1±84, respectively). Highest isolated Tc 99m MAG3 clearances among normal functioning kidneys were observed in group 1 (281.5±45.6) followed by group 2 (204.4±55) and group 3 (157.5±44). Moderate negative correlation was detected between the Tc99m MAG3 clearances of normal kidneys and contralateral renal function (r=-0.5, p<0.001). Conclusion: Normal kidneys can compensate for the loss of contralateral kidney function via increasing their clearances, which seems to be dependent on the residual function of their partner. Camera based Tc 99m MAG3 clearance measurement is an objective method to demonstrate compensatory differences in renal function seen between kidneys with contralateral normofunctioning, hypofunctioning and nonfunctioning partner. Conflict of interest:None declared. Galenos Publishing 2012-08 2012-08-01 /pmc/articles/PMC3590969/ /pubmed/23486848 http://dx.doi.org/10.4274/Mirt.309 Text en © Molecular Imaging and Radionuclide Therapy, Published by Galenos Publishing. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Akkaş, Burcu Esen
Vural, Gülin Uçmak
Akdemir, Ümit Özgür
Karabacak, Neşe İlgin
Demonstration of Adaptive Functional Differences Seen in Kidneys Accompanying a Nonfunctioning/Hypofunctioning Partner, using Camera Based Tc 99m MAG3 Clearance Measurement Technique
title Demonstration of Adaptive Functional Differences Seen in Kidneys Accompanying a Nonfunctioning/Hypofunctioning Partner, using Camera Based Tc 99m MAG3 Clearance Measurement Technique
title_full Demonstration of Adaptive Functional Differences Seen in Kidneys Accompanying a Nonfunctioning/Hypofunctioning Partner, using Camera Based Tc 99m MAG3 Clearance Measurement Technique
title_fullStr Demonstration of Adaptive Functional Differences Seen in Kidneys Accompanying a Nonfunctioning/Hypofunctioning Partner, using Camera Based Tc 99m MAG3 Clearance Measurement Technique
title_full_unstemmed Demonstration of Adaptive Functional Differences Seen in Kidneys Accompanying a Nonfunctioning/Hypofunctioning Partner, using Camera Based Tc 99m MAG3 Clearance Measurement Technique
title_short Demonstration of Adaptive Functional Differences Seen in Kidneys Accompanying a Nonfunctioning/Hypofunctioning Partner, using Camera Based Tc 99m MAG3 Clearance Measurement Technique
title_sort demonstration of adaptive functional differences seen in kidneys accompanying a nonfunctioning/hypofunctioning partner, using camera based tc 99m mag3 clearance measurement technique
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590969/
https://www.ncbi.nlm.nih.gov/pubmed/23486848
http://dx.doi.org/10.4274/Mirt.309
work_keys_str_mv AT akkasburcuesen demonstrationofadaptivefunctionaldifferencesseeninkidneysaccompanyinganonfunctioninghypofunctioningpartnerusingcamerabasedtc99mmag3clearancemeasurementtechnique
AT vuralgulinucmak demonstrationofadaptivefunctionaldifferencesseeninkidneysaccompanyinganonfunctioninghypofunctioningpartnerusingcamerabasedtc99mmag3clearancemeasurementtechnique
AT akdemirumitozgur demonstrationofadaptivefunctionaldifferencesseeninkidneysaccompanyinganonfunctioninghypofunctioningpartnerusingcamerabasedtc99mmag3clearancemeasurementtechnique
AT karabacakneseilgin demonstrationofadaptivefunctionaldifferencesseeninkidneysaccompanyinganonfunctioninghypofunctioningpartnerusingcamerabasedtc99mmag3clearancemeasurementtechnique