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A common variant in Myosin-18B contributes to mathematical abilities in children with dyslexia and intraparietal sulcus variability in adults
The ability to perform mathematical tasks is required in everyday life. Although heritability estimates suggest a genetic contribution, no previous study has conclusively identified a genetic risk variant for mathematical performance. Research has shown that the prevalence of mathematical disabiliti...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591001/ https://www.ncbi.nlm.nih.gov/pubmed/23423138 http://dx.doi.org/10.1038/tp.2012.148 |
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author | Ludwig, K U Sämann, P Alexander, M Becker, J Bruder, J Moll, K Spieler, D Czisch, M Warnke, A Docherty, S J Davis, O S P Plomin, R Nöthen, M M Landerl, K Müller-Myhsok, B Hoffmann, P Schumacher, J Schulte-Körne, G Czamara, D |
author_facet | Ludwig, K U Sämann, P Alexander, M Becker, J Bruder, J Moll, K Spieler, D Czisch, M Warnke, A Docherty, S J Davis, O S P Plomin, R Nöthen, M M Landerl, K Müller-Myhsok, B Hoffmann, P Schumacher, J Schulte-Körne, G Czamara, D |
author_sort | Ludwig, K U |
collection | PubMed |
description | The ability to perform mathematical tasks is required in everyday life. Although heritability estimates suggest a genetic contribution, no previous study has conclusively identified a genetic risk variant for mathematical performance. Research has shown that the prevalence of mathematical disabilities is increased in children with dyslexia. We therefore correlated genome-wide data of 200 German children with spelling disability, with available quantitative data on mathematic ability. Replication of the top findings in additional dyslexia samples revealed that rs133885 was a genome-wide significant marker for mathematical abilities (P(comb)=7.71 × 10(−10), n=699), with an effect size of 4.87%. This association was also found in a sample from the general population (P=0.048, n=1080), albeit with a lower effect size. The identified variant encodes an amino-acid substitution in MYO18B, a protein with as yet unknown functions in the brain. As areas of the parietal cortex, in particular the intraparietal sulcus (IPS), are involved in numerical processing in humans, we investigated whether rs133885 was associated with IPS morphology using structural magnetic resonance imaging data from 79 neuropsychiatrically healthy adults. Carriers of the MYO18B risk-genotype displayed a significantly lower depth of the right IPS. This validates the identified association between rs133885 and mathematical disability at the level of a specific intermediate phenotype. |
format | Online Article Text |
id | pubmed-3591001 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-35910012013-03-12 A common variant in Myosin-18B contributes to mathematical abilities in children with dyslexia and intraparietal sulcus variability in adults Ludwig, K U Sämann, P Alexander, M Becker, J Bruder, J Moll, K Spieler, D Czisch, M Warnke, A Docherty, S J Davis, O S P Plomin, R Nöthen, M M Landerl, K Müller-Myhsok, B Hoffmann, P Schumacher, J Schulte-Körne, G Czamara, D Transl Psychiatry Original Article The ability to perform mathematical tasks is required in everyday life. Although heritability estimates suggest a genetic contribution, no previous study has conclusively identified a genetic risk variant for mathematical performance. Research has shown that the prevalence of mathematical disabilities is increased in children with dyslexia. We therefore correlated genome-wide data of 200 German children with spelling disability, with available quantitative data on mathematic ability. Replication of the top findings in additional dyslexia samples revealed that rs133885 was a genome-wide significant marker for mathematical abilities (P(comb)=7.71 × 10(−10), n=699), with an effect size of 4.87%. This association was also found in a sample from the general population (P=0.048, n=1080), albeit with a lower effect size. The identified variant encodes an amino-acid substitution in MYO18B, a protein with as yet unknown functions in the brain. As areas of the parietal cortex, in particular the intraparietal sulcus (IPS), are involved in numerical processing in humans, we investigated whether rs133885 was associated with IPS morphology using structural magnetic resonance imaging data from 79 neuropsychiatrically healthy adults. Carriers of the MYO18B risk-genotype displayed a significantly lower depth of the right IPS. This validates the identified association between rs133885 and mathematical disability at the level of a specific intermediate phenotype. Nature Publishing Group 2013-02 2013-02-19 /pmc/articles/PMC3591001/ /pubmed/23423138 http://dx.doi.org/10.1038/tp.2012.148 Text en Copyright © 2013 Macmillan Publishers Limited http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/ |
spellingShingle | Original Article Ludwig, K U Sämann, P Alexander, M Becker, J Bruder, J Moll, K Spieler, D Czisch, M Warnke, A Docherty, S J Davis, O S P Plomin, R Nöthen, M M Landerl, K Müller-Myhsok, B Hoffmann, P Schumacher, J Schulte-Körne, G Czamara, D A common variant in Myosin-18B contributes to mathematical abilities in children with dyslexia and intraparietal sulcus variability in adults |
title | A common variant in Myosin-18B contributes to mathematical abilities in children with dyslexia and intraparietal sulcus variability in adults |
title_full | A common variant in Myosin-18B contributes to mathematical abilities in children with dyslexia and intraparietal sulcus variability in adults |
title_fullStr | A common variant in Myosin-18B contributes to mathematical abilities in children with dyslexia and intraparietal sulcus variability in adults |
title_full_unstemmed | A common variant in Myosin-18B contributes to mathematical abilities in children with dyslexia and intraparietal sulcus variability in adults |
title_short | A common variant in Myosin-18B contributes to mathematical abilities in children with dyslexia and intraparietal sulcus variability in adults |
title_sort | common variant in myosin-18b contributes to mathematical abilities in children with dyslexia and intraparietal sulcus variability in adults |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591001/ https://www.ncbi.nlm.nih.gov/pubmed/23423138 http://dx.doi.org/10.1038/tp.2012.148 |
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