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High-grade chondroblastic and fibroblastic osteosarcoma of the upper jaw

Osteosarcomas (OS) are extremely uncommon in maxillofacial region (6%-10% of all sarcomas). Jaw lesions are diagnosed on average two decades later than sarcomas of long bone, with a peak incidence between 20 and 40 years. Head and neck OS (HNOS) are associated with a lower metastatic rate than long...

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Autores principales: Cutilli, Tommaso, Scarsella, Secondo, Fabio, Desiderio Di, Oliva, Antonio, Cargini, Pasqualino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591009/
https://www.ncbi.nlm.nih.gov/pubmed/23482406
http://dx.doi.org/10.4103/2231-0746.92790
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author Cutilli, Tommaso
Scarsella, Secondo
Fabio, Desiderio Di
Oliva, Antonio
Cargini, Pasqualino
author_facet Cutilli, Tommaso
Scarsella, Secondo
Fabio, Desiderio Di
Oliva, Antonio
Cargini, Pasqualino
author_sort Cutilli, Tommaso
collection PubMed
description Osteosarcomas (OS) are extremely uncommon in maxillofacial region (6%-10% of all sarcomas). Jaw lesions are diagnosed on average two decades later than sarcomas of long bone, with a peak incidence between 20 and 40 years. Head and neck OS (HNOS) are associated with a lower metastatic rate than long bone OS, and they have a better 5-year survival rate, ranging between 27% and 84%. Approximately 80% of HNOS originate from soft tissues, while 20% arise from bone. The majority of OS were classified as osteoblastic HNOS (77.0%), followed by chondroblastic (15.8%) and fibroblastic (3.4%). Patients older than 60 years were more likely to be diagnosed with other histologic types compared with patients 60 years or younger. The authors describe a rare case of Stage II high-grade mixed chondroblastic and fibroblastic osteosarcoma of the upper jaw diagnosed in a subject older than 60 years. CT i.e., total body scintigraphy, radiograph of chest, and epathic ultrasonography have been executed to staging (T3N0M0). The size of the tumor >6 cm, histopathological findings, and patient older than 60 years, made necessary a multimodality therapy. Surgery (right subtotal maxillectomy with closure of surgical area by local sliding and advanced cheek flap) and adjuvant radiotherapy (for overall 6500 Gy) were the definitive treatment. Follow-up at 2 years shows no local recurrence and the patient is disease free.
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spelling pubmed-35910092013-03-11 High-grade chondroblastic and fibroblastic osteosarcoma of the upper jaw Cutilli, Tommaso Scarsella, Secondo Fabio, Desiderio Di Oliva, Antonio Cargini, Pasqualino Ann Maxillofac Surg Case Report - Surgical Pathology Osteosarcomas (OS) are extremely uncommon in maxillofacial region (6%-10% of all sarcomas). Jaw lesions are diagnosed on average two decades later than sarcomas of long bone, with a peak incidence between 20 and 40 years. Head and neck OS (HNOS) are associated with a lower metastatic rate than long bone OS, and they have a better 5-year survival rate, ranging between 27% and 84%. Approximately 80% of HNOS originate from soft tissues, while 20% arise from bone. The majority of OS were classified as osteoblastic HNOS (77.0%), followed by chondroblastic (15.8%) and fibroblastic (3.4%). Patients older than 60 years were more likely to be diagnosed with other histologic types compared with patients 60 years or younger. The authors describe a rare case of Stage II high-grade mixed chondroblastic and fibroblastic osteosarcoma of the upper jaw diagnosed in a subject older than 60 years. CT i.e., total body scintigraphy, radiograph of chest, and epathic ultrasonography have been executed to staging (T3N0M0). The size of the tumor >6 cm, histopathological findings, and patient older than 60 years, made necessary a multimodality therapy. Surgery (right subtotal maxillectomy with closure of surgical area by local sliding and advanced cheek flap) and adjuvant radiotherapy (for overall 6500 Gy) were the definitive treatment. Follow-up at 2 years shows no local recurrence and the patient is disease free. Medknow Publications & Media Pvt Ltd 2011 /pmc/articles/PMC3591009/ /pubmed/23482406 http://dx.doi.org/10.4103/2231-0746.92790 Text en Copyright: © Annals of Maxillofacial Surgery http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report - Surgical Pathology
Cutilli, Tommaso
Scarsella, Secondo
Fabio, Desiderio Di
Oliva, Antonio
Cargini, Pasqualino
High-grade chondroblastic and fibroblastic osteosarcoma of the upper jaw
title High-grade chondroblastic and fibroblastic osteosarcoma of the upper jaw
title_full High-grade chondroblastic and fibroblastic osteosarcoma of the upper jaw
title_fullStr High-grade chondroblastic and fibroblastic osteosarcoma of the upper jaw
title_full_unstemmed High-grade chondroblastic and fibroblastic osteosarcoma of the upper jaw
title_short High-grade chondroblastic and fibroblastic osteosarcoma of the upper jaw
title_sort high-grade chondroblastic and fibroblastic osteosarcoma of the upper jaw
topic Case Report - Surgical Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591009/
https://www.ncbi.nlm.nih.gov/pubmed/23482406
http://dx.doi.org/10.4103/2231-0746.92790
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