HOXA4 Gene Promoter Hypermethylation as an Epigenetic Mechanism Mediating Resistance to Imatinib Mesylate in Chronic Myeloid Leukemia Patients

Development of resistance to imatinib mesylate (IM) in chronic myeloid leukemia (CML) patients has emerged as a significant clinical problem. The observation that increased epigenetic silencing of potential tumor suppressor genes correlates with disease progression in some CML patients treated with...

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Detalles Bibliográficos
Autores principales: Elias, Marjanu Hikmah, Baba, Abdul Aziz, Husin, Azlan, Sulong, Sarina, Hassan, Rosline, Sim, Goh Ai, Abdul Wahid, S. Fadilah, Ankathil, Ravindran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591123/
https://www.ncbi.nlm.nih.gov/pubmed/23484077
http://dx.doi.org/10.1155/2013/129715

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591123/
https://www.ncbi.nlm.nih.gov/pubmed/23484077
http://dx.doi.org/10.1155/2013/129715

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