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Association between Polymorphisms of Alpha-Adducin Gene and Essential Hypertension in Chinese Population
The association between polymorphisms of α-adducin (ADD1) gene and essential hypertension is still unclear. Thus, we carried out a case-control study and an interaction analysis to test whether ADD1 is a common candidate gene for hypertension in the Chinese population. Blood samples and information...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591139/ https://www.ncbi.nlm.nih.gov/pubmed/23509723 http://dx.doi.org/10.1155/2013/451094 |
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author | Zhang, Li-na Ji, Lin-dan Fei, Li-juan Yuan, Fang Zhang, Yue-miao Xu, Jin |
author_facet | Zhang, Li-na Ji, Lin-dan Fei, Li-juan Yuan, Fang Zhang, Yue-miao Xu, Jin |
author_sort | Zhang, Li-na |
collection | PubMed |
description | The association between polymorphisms of α-adducin (ADD1) gene and essential hypertension is still unclear. Thus, we carried out a case-control study and an interaction analysis to test whether ADD1 is a common candidate gene for hypertension in the Chinese population. Blood samples and information including body mass index (BMI), smoking habit, and alcohol abuse were collected. Meanwhile, total cholesterol, high density lipoprotein, triglyceride were measured by automatic biochemistry analyzer. All 6 tag single nucleotide polymorphisms (tagSNPs) within ADD1 gene were genotyped by SNPstream genotyping system. Multifactor dimensionality reduction (MDR) was used to identify the interactions among the SNPs and the non-genetic factors. Results showed that plasma triglyceride, total cholesterol, and BMI were significantly higher in the hypertensive group than in the control group. Result from genotyping indicated that rs4963 was significantly associated with essential hypertension. After stratification by gender, rs4963 was associated with essential hypertension only in males. MDR analysis indicated that interaction among BMI, rs4963, and rs16843452 were involved in susceptibility of hypertension. The present study indicated that rs4963 within ADD1 gene was associated with essential hypertension in Chinese population, which might be related to altered exonic splicing and disrupted gene regulation. |
format | Online Article Text |
id | pubmed-3591139 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-35911392013-03-18 Association between Polymorphisms of Alpha-Adducin Gene and Essential Hypertension in Chinese Population Zhang, Li-na Ji, Lin-dan Fei, Li-juan Yuan, Fang Zhang, Yue-miao Xu, Jin Biomed Res Int Research Article The association between polymorphisms of α-adducin (ADD1) gene and essential hypertension is still unclear. Thus, we carried out a case-control study and an interaction analysis to test whether ADD1 is a common candidate gene for hypertension in the Chinese population. Blood samples and information including body mass index (BMI), smoking habit, and alcohol abuse were collected. Meanwhile, total cholesterol, high density lipoprotein, triglyceride were measured by automatic biochemistry analyzer. All 6 tag single nucleotide polymorphisms (tagSNPs) within ADD1 gene were genotyped by SNPstream genotyping system. Multifactor dimensionality reduction (MDR) was used to identify the interactions among the SNPs and the non-genetic factors. Results showed that plasma triglyceride, total cholesterol, and BMI were significantly higher in the hypertensive group than in the control group. Result from genotyping indicated that rs4963 was significantly associated with essential hypertension. After stratification by gender, rs4963 was associated with essential hypertension only in males. MDR analysis indicated that interaction among BMI, rs4963, and rs16843452 were involved in susceptibility of hypertension. The present study indicated that rs4963 within ADD1 gene was associated with essential hypertension in Chinese population, which might be related to altered exonic splicing and disrupted gene regulation. Hindawi Publishing Corporation 2013 2012-12-20 /pmc/articles/PMC3591139/ /pubmed/23509723 http://dx.doi.org/10.1155/2013/451094 Text en Copyright © 2013 Li-na Zhang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Zhang, Li-na Ji, Lin-dan Fei, Li-juan Yuan, Fang Zhang, Yue-miao Xu, Jin Association between Polymorphisms of Alpha-Adducin Gene and Essential Hypertension in Chinese Population |
title | Association between Polymorphisms of Alpha-Adducin Gene and Essential Hypertension in Chinese Population |
title_full | Association between Polymorphisms of Alpha-Adducin Gene and Essential Hypertension in Chinese Population |
title_fullStr | Association between Polymorphisms of Alpha-Adducin Gene and Essential Hypertension in Chinese Population |
title_full_unstemmed | Association between Polymorphisms of Alpha-Adducin Gene and Essential Hypertension in Chinese Population |
title_short | Association between Polymorphisms of Alpha-Adducin Gene and Essential Hypertension in Chinese Population |
title_sort | association between polymorphisms of alpha-adducin gene and essential hypertension in chinese population |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591139/ https://www.ncbi.nlm.nih.gov/pubmed/23509723 http://dx.doi.org/10.1155/2013/451094 |
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