Cargando…

Alantolactone Induces Apoptosis in HepG2 Cells through GSH Depletion, Inhibition of STAT3 Activation, and Mitochondrial Dysfunction

Signal transducer and activator of transcription 3 (STAT3) constitutively expresses in human liver cancer cells and has been implicated in apoptosis resistance and tumorigenesis. Alantolactone, a sesquiterpene lactone, has been shown to possess anticancer activities in various cancer cell lines. In...

Descripción completa

Detalles Bibliográficos
Autores principales:	Khan, Muhammad, Li, Ting, Ahmad Khan, Muhammad Khalil, Rasul, Azhar, Nawaz, Faisal, Sun, Meiyan, Zheng, Yongchen, Ma, Tonghui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591150/ https://www.ncbi.nlm.nih.gov/pubmed/23533997 http://dx.doi.org/10.1155/2013/719858

Ejemplares similares

Targeting Apoptosis Pathways in Cancer with Alantolactone and Isoalantolactone
por: Rasul, Azhar, et al.
Publicado: (2013)

Santamarine Inhibits NF-кB and STAT3 Activation and Induces Apoptosis in HepG2 Liver Cancer Cells via Oxidative Stress.
por: Mehmood, Tahir, et al.
Publicado: (2017)

Alantolactone induces apoptosis, promotes STAT3 glutathionylation and enhances chemosensitivity of A549 lung adenocarcinoma cells to doxorubicin via oxidative stress
por: Maryam, Amara, et al.
Publicado: (2017)

Nrf2 mediates the protective effects of homocysteine by increasing the levels of GSH content in HepG2 cells
por: Zhang, Bing, et al.
Publicado: (2017)

Nevirapine induced mitochondrial dysfunction in HepG2 cells
por: Paemanee, Atchara, et al.
Publicado: (2017)

Folic acid depletion as well as oversupplementation helps in the progression of hepatocarcinogenesis in HepG2 cells
por: Sharma, Renuka, et al.
Publicado: (2022)

TMEM2 inhibits hepatitis B virus infection in HepG2 and HepG2.2.15 cells by activating the JAK–STAT signaling pathway
por: Zhu, X, et al.
Publicado: (2016)

Magnolol, a natural compound, induces apoptosis of SGC-7901 human gastric adenocarcinoma cells via the mitochondrial and PI3K/Akt signaling pathways
por: RASUL, AZHAR, et al.
Publicado: (2011)

BTEAC Catalyzed Ultrasonic-Assisted Synthesis of Bromobenzofuran-Oxadiazoles: Unravelling Anti-HepG-2 Cancer Therapeutic Potential through In Vitro and In Silico Studies
por: Irfan, Ali, et al.
Publicado: (2023)

Jaceosidin Induces Apoptosis in U87 Glioblastoma Cells through G2/M Phase Arrest
por: Khan, Muhammad, et al.
Publicado: (2012)

Impact of HepG2 Cells Glutathione Depletion on Neutral Sphingomyelinases mRNA Levels and Activity
por: Gamal, Marie, et al.
Publicado: (2023)

Brevilin A Inhibits STAT3 Signaling and Induces ROS-Dependent Apoptosis, Mitochondrial Stress and Endoplasmic Reticulum Stress in MCF-7 Breast Cancer Cells
por: Saleem, Muhammad Zubair, et al.
Publicado: (2020)

Triggering of Programmed Erythrocyte Death by Alantolactone
por: Alzoubi, Kousi, et al.
Publicado: (2014)

Induction of Apoptosis and Cytotoxicity by Isothiocyanate Sulforaphene in Human Hepatocarcinoma HepG2 Cells
por: Kntayya, Saie Brindha, et al.
Publicado: (2018)

Selective STAT3 Inhibitor Alantolactone Ameliorates Osteoarthritis via Regulating Chondrocyte Autophagy and Cartilage Homeostasis
por: Pei, Wenbin, et al.
Publicado: (2021)

Augmentation of Glucotoxicity, Oxidative Stress, Apoptosis and Mitochondrial Dysfunction in HepG2 Cells by Palmitic Acid
por: Alnahdi, Arwa, et al.
Publicado: (2019)

GSH depletion liposome adjuvant for augmenting the photothermal immunotherapy of breast cancer
por: Zhou, Zhanwei, et al.
Publicado: (2020)

Biomimetic CuS nanoparticles for radiosensitization with mild photothermal therapy and GSH-depletion
por: Zhou, Xiaoxiang, et al.
Publicado: (2022)

Furosine Induced Apoptosis by the Regulation of STAT1/STAT2 and UBA7/UBE2L6 Genes in HepG2 Cells
por: Li, Huiying, et al.
Publicado: (2018)

Depletion of Cks1 and Cks2 expression compromises cell proliferation and enhance chemotherapy-induced apoptosis in HepG2 cells
por: LIN, LINGQING, et al.
Publicado: (2016)

Naringenin Induces HepG2 Cell Apoptosis via ROS-Mediated JAK-2/STAT-3 Signaling Pathways
por: Zhang, Ming, et al.
Publicado: (2023)

Transporter-Mediated Mitochondrial GSH Depletion Leading to Mitochondrial Dysfunction and Rescue with αB Crystallin Peptide in RPE Cells
por: Sreekumar, Parameswaran G, et al.
Publicado: (2020)

Dual Targeting EGFR and STAT3 With Erlotinib and Alantolactone Co-Loaded PLGA Nanoparticles for Pancreatic Cancer Treatment
por: Bao, Shihui, et al.
Publicado: (2021)

Synergistic Activity of Ketoconazole and Miconazole with Prochloraz in Inducing Oxidative Stress, GSH Depletion, Mitochondrial Dysfunction, and Apoptosis in Mouse Sertoli TM4 Cells
por: Petricca, Sabrina, et al.
Publicado: (2022)

Cytotoxic Activity of Phytoconstituents Isolated from Monotheca buxifolia against Hepatocellular Carcinoma Cell Line HepG2: In Vitro and Molecular Docking Studies
por: Hassan, Said, et al.
Publicado: (2023)

Alantolactone alleviates collagen-induced arthritis and inhibits Th17 cell differentiation through modulation of STAT3 signalling
por: Chen, Hsiang-Lai, et al.
Publicado: (2021)

Inhibition of JNK-Mediated Autophagy Promotes Proscillaridin A- Induced Apoptosis via ROS Generation, Intracellular Ca(+2) Oscillation and Inhibiting STAT3 Signaling in Breast Cancer Cells
por: Saleem, Muhammad Zubair, et al.
Publicado: (2020)

HCMV Activates the IL-6-JAK-STAT3 Axis in HepG2 Cells and Primary Human Hepatocytes
por: Lepiller, Quentin, et al.
Publicado: (2013)

Polyphyllin VII induces apoptosis in HepG2 cells through ROS-mediated mitochondrial dysfunction and MAPK pathways
por: Zhang, Chao, et al.
Publicado: (2016)

Artificial cells eavesdropping on HepG2 cells
por: Westensee, Isabella Nymann, et al.
Publicado: (2023)

Suaeda vermiculata Aqueous-Ethanolic Extract-Based Mitigation of CCl(4)-Induced Hepatotoxicity in Rats, and HepG-2 and HepG-2/ADR Cell-Lines-Based Cytotoxicity Evaluations
por: Mohammed, Salman A. A., et al.
Publicado: (2020)

Pseudolaric Acid B Induces Caspase-Dependent and Caspase-Independent Apoptosis in U87 Glioblastoma Cells
por: Khan, Muhammad, et al.
Publicado: (2012)

Bio-Oriented Synthesis and Molecular Docking Studies of 1,2,4-Triazole Based Derivatives as Potential Anti-Cancer Agents against HepG2 Cell Line
por: Akhter, Naheed, et al.
Publicado: (2023)

Corrigendum to “Pseudolaric Acid B Induces Caspase-Dependent and Caspase-Independent Apoptosis in U87 Glioblastoma Cells”
por: Khan, Muhammad, et al.
Publicado: (2020)

Streptozotocin-Induced Cytotoxicity, Oxidative Stress and Mitochondrial Dysfunction in Human Hepatoma HepG2 Cells
por: Raza, Haider, et al.
Publicado: (2012)

Sodium Butyrate-Modulated Mitochondrial Function in High-Insulin Induced HepG2 Cell Dysfunction
por: Zhao, Tingting, et al.
Publicado: (2020)

2,4,6-Trinitrotoluene Induces Apoptosis via ROS-Regulated Mitochondrial Dysfunction and Endoplasmic Reticulum Stress in HepG2 and Hep3B Cells
por: Liao, Hung-Yu, et al.
Publicado: (2017)

HepG2-NTCP Subclones Exhibiting High Susceptibility to Hepatitis B Virus Infection
por: Zahoor, Muhammad Atif, et al.
Publicado: (2022)

Serum Oxidative Stress-Induced Repression of Nrf2 and GSH Depletion: A Mechanism Potentially Involved in Endothelial Dysfunction of Young Smokers
por: Fratta Pasini, Anna, et al.
Publicado: (2012)

Embelin-induced apoptosis of HepG2 human hepatocellular carcinoma cells and blockade of HepG2 cells in the G2/M phase via the mitochondrial pathway
por: TAGHIYEV, ASAF, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_qj3u9uvi848vhbkqur93i6jd74