Cargando…

A MicroRNA Component of the Neoplastic Microenvironment: Microregulators with Far-Reaching Impact

The interplay between tumor cells and their microenvironment plays a pivotal role in tumor development and progression. Although a growing body of evidence has established the importance of the tumor microenvironment, an understanding of the crosstalk between its components and cancer cells remains...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Xiaolei, Wu, Zhiqiang, Fu, Xiaobing, Han, Weidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591172/
https://www.ncbi.nlm.nih.gov/pubmed/23509776
http://dx.doi.org/10.1155/2013/762183
_version_ 1782261996425576448
author Li, Xiaolei
Wu, Zhiqiang
Fu, Xiaobing
Han, Weidong
author_facet Li, Xiaolei
Wu, Zhiqiang
Fu, Xiaobing
Han, Weidong
author_sort Li, Xiaolei
collection PubMed
description The interplay between tumor cells and their microenvironment plays a pivotal role in tumor development and progression. Although a growing body of evidence has established the importance of the tumor microenvironment, an understanding of the crosstalk between its components and cancer cells remains elusive. The pathways triggered by microenvironmental factors could modulate cancer-related gene transcription, also affecting small noncoding RNAs, microRNAs, which have emerged as key posttranscriptional regulators of gene expression, directly involved in human cancers. Although microRNAs regulate most biological mechanisms, their role in the tumor microenvironment has only recently become the focus of intense research. In this paper, we focus on the intertwined connection between the tumor microenvironment and aberrant expression of microRNAs involved in carcinogenesis. We also discuss the emerging roles of microRNAs in the tumor microenvironment as it relates to cancer progression. We conclude that microRNAs are critical for our understanding of the development of cancer, and that targeting microRNA signaling pathways in the microenvironment as well as in tumor cells opens new therapeutic avenues to the global control of cancer.
format Online
Article
Text
id pubmed-3591172
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-35911722013-03-18 A MicroRNA Component of the Neoplastic Microenvironment: Microregulators with Far-Reaching Impact Li, Xiaolei Wu, Zhiqiang Fu, Xiaobing Han, Weidong Biomed Res Int Review Article The interplay between tumor cells and their microenvironment plays a pivotal role in tumor development and progression. Although a growing body of evidence has established the importance of the tumor microenvironment, an understanding of the crosstalk between its components and cancer cells remains elusive. The pathways triggered by microenvironmental factors could modulate cancer-related gene transcription, also affecting small noncoding RNAs, microRNAs, which have emerged as key posttranscriptional regulators of gene expression, directly involved in human cancers. Although microRNAs regulate most biological mechanisms, their role in the tumor microenvironment has only recently become the focus of intense research. In this paper, we focus on the intertwined connection between the tumor microenvironment and aberrant expression of microRNAs involved in carcinogenesis. We also discuss the emerging roles of microRNAs in the tumor microenvironment as it relates to cancer progression. We conclude that microRNAs are critical for our understanding of the development of cancer, and that targeting microRNA signaling pathways in the microenvironment as well as in tumor cells opens new therapeutic avenues to the global control of cancer. Hindawi Publishing Corporation 2013 2012-12-04 /pmc/articles/PMC3591172/ /pubmed/23509776 http://dx.doi.org/10.1155/2013/762183 Text en Copyright © 2013 Xiaolei Li et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Li, Xiaolei
Wu, Zhiqiang
Fu, Xiaobing
Han, Weidong
A MicroRNA Component of the Neoplastic Microenvironment: Microregulators with Far-Reaching Impact
title A MicroRNA Component of the Neoplastic Microenvironment: Microregulators with Far-Reaching Impact
title_full A MicroRNA Component of the Neoplastic Microenvironment: Microregulators with Far-Reaching Impact
title_fullStr A MicroRNA Component of the Neoplastic Microenvironment: Microregulators with Far-Reaching Impact
title_full_unstemmed A MicroRNA Component of the Neoplastic Microenvironment: Microregulators with Far-Reaching Impact
title_short A MicroRNA Component of the Neoplastic Microenvironment: Microregulators with Far-Reaching Impact
title_sort microrna component of the neoplastic microenvironment: microregulators with far-reaching impact
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591172/
https://www.ncbi.nlm.nih.gov/pubmed/23509776
http://dx.doi.org/10.1155/2013/762183
work_keys_str_mv AT lixiaolei amicrornacomponentoftheneoplasticmicroenvironmentmicroregulatorswithfarreachingimpact
AT wuzhiqiang amicrornacomponentoftheneoplasticmicroenvironmentmicroregulatorswithfarreachingimpact
AT fuxiaobing amicrornacomponentoftheneoplasticmicroenvironmentmicroregulatorswithfarreachingimpact
AT hanweidong amicrornacomponentoftheneoplasticmicroenvironmentmicroregulatorswithfarreachingimpact
AT lixiaolei micrornacomponentoftheneoplasticmicroenvironmentmicroregulatorswithfarreachingimpact
AT wuzhiqiang micrornacomponentoftheneoplasticmicroenvironmentmicroregulatorswithfarreachingimpact
AT fuxiaobing micrornacomponentoftheneoplasticmicroenvironmentmicroregulatorswithfarreachingimpact
AT hanweidong micrornacomponentoftheneoplasticmicroenvironmentmicroregulatorswithfarreachingimpact