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Growth Induction and Low-Oxygen Apoptosis Inhibition of Human CD34(+) Progenitors in Collagen Gels
Various reports have indicated low survival of injected progenitors into unfavorable environments such as the ischemic myocardium or lower limb tissues. This represents a major bottleneck in stem-cell-based cardiovascular regenerative medicine. Strategies to enhance survival of these cells in recipi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591191/ https://www.ncbi.nlm.nih.gov/pubmed/23509738 http://dx.doi.org/10.1155/2013/542810 |
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author | Avitabile, Daniele Salchert, Katrin Werner, Carsten Capogrossi, Maurizio C. Pesce, Maurizio |
author_facet | Avitabile, Daniele Salchert, Katrin Werner, Carsten Capogrossi, Maurizio C. Pesce, Maurizio |
author_sort | Avitabile, Daniele |
collection | PubMed |
description | Various reports have indicated low survival of injected progenitors into unfavorable environments such as the ischemic myocardium or lower limb tissues. This represents a major bottleneck in stem-cell-based cardiovascular regenerative medicine. Strategies to enhance survival of these cells in recipient tissues have been therefore sought to improve stem cell survival and ensure long-term engraftment. In the present contribution, we show that embedding human cord blood-derived CD34(+) cells into a collagen I-based hydrogel containing cytokines is a suitable strategy to promote stem cell proliferation and protect these cells from anoxia-induced apoptosis. |
format | Online Article Text |
id | pubmed-3591191 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-35911912013-03-18 Growth Induction and Low-Oxygen Apoptosis Inhibition of Human CD34(+) Progenitors in Collagen Gels Avitabile, Daniele Salchert, Katrin Werner, Carsten Capogrossi, Maurizio C. Pesce, Maurizio Biomed Res Int Research Article Various reports have indicated low survival of injected progenitors into unfavorable environments such as the ischemic myocardium or lower limb tissues. This represents a major bottleneck in stem-cell-based cardiovascular regenerative medicine. Strategies to enhance survival of these cells in recipient tissues have been therefore sought to improve stem cell survival and ensure long-term engraftment. In the present contribution, we show that embedding human cord blood-derived CD34(+) cells into a collagen I-based hydrogel containing cytokines is a suitable strategy to promote stem cell proliferation and protect these cells from anoxia-induced apoptosis. Hindawi Publishing Corporation 2013 2012-12-27 /pmc/articles/PMC3591191/ /pubmed/23509738 http://dx.doi.org/10.1155/2013/542810 Text en Copyright © 2013 Daniele Avitabile et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Avitabile, Daniele Salchert, Katrin Werner, Carsten Capogrossi, Maurizio C. Pesce, Maurizio Growth Induction and Low-Oxygen Apoptosis Inhibition of Human CD34(+) Progenitors in Collagen Gels |
title | Growth Induction and Low-Oxygen Apoptosis Inhibition of Human CD34(+) Progenitors in Collagen Gels |
title_full | Growth Induction and Low-Oxygen Apoptosis Inhibition of Human CD34(+) Progenitors in Collagen Gels |
title_fullStr | Growth Induction and Low-Oxygen Apoptosis Inhibition of Human CD34(+) Progenitors in Collagen Gels |
title_full_unstemmed | Growth Induction and Low-Oxygen Apoptosis Inhibition of Human CD34(+) Progenitors in Collagen Gels |
title_short | Growth Induction and Low-Oxygen Apoptosis Inhibition of Human CD34(+) Progenitors in Collagen Gels |
title_sort | growth induction and low-oxygen apoptosis inhibition of human cd34(+) progenitors in collagen gels |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591191/ https://www.ncbi.nlm.nih.gov/pubmed/23509738 http://dx.doi.org/10.1155/2013/542810 |
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