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Growth Induction and Low-Oxygen Apoptosis Inhibition of Human CD34(+) Progenitors in Collagen Gels

Various reports have indicated low survival of injected progenitors into unfavorable environments such as the ischemic myocardium or lower limb tissues. This represents a major bottleneck in stem-cell-based cardiovascular regenerative medicine. Strategies to enhance survival of these cells in recipi...

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Detalles Bibliográficos
Autores principales: Avitabile, Daniele, Salchert, Katrin, Werner, Carsten, Capogrossi, Maurizio C., Pesce, Maurizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591191/
https://www.ncbi.nlm.nih.gov/pubmed/23509738
http://dx.doi.org/10.1155/2013/542810
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author Avitabile, Daniele
Salchert, Katrin
Werner, Carsten
Capogrossi, Maurizio C.
Pesce, Maurizio
author_facet Avitabile, Daniele
Salchert, Katrin
Werner, Carsten
Capogrossi, Maurizio C.
Pesce, Maurizio
author_sort Avitabile, Daniele
collection PubMed
description Various reports have indicated low survival of injected progenitors into unfavorable environments such as the ischemic myocardium or lower limb tissues. This represents a major bottleneck in stem-cell-based cardiovascular regenerative medicine. Strategies to enhance survival of these cells in recipient tissues have been therefore sought to improve stem cell survival and ensure long-term engraftment. In the present contribution, we show that embedding human cord blood-derived CD34(+) cells into a collagen I-based hydrogel containing cytokines is a suitable strategy to promote stem cell proliferation and protect these cells from anoxia-induced apoptosis.
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spelling pubmed-35911912013-03-18 Growth Induction and Low-Oxygen Apoptosis Inhibition of Human CD34(+) Progenitors in Collagen Gels Avitabile, Daniele Salchert, Katrin Werner, Carsten Capogrossi, Maurizio C. Pesce, Maurizio Biomed Res Int Research Article Various reports have indicated low survival of injected progenitors into unfavorable environments such as the ischemic myocardium or lower limb tissues. This represents a major bottleneck in stem-cell-based cardiovascular regenerative medicine. Strategies to enhance survival of these cells in recipient tissues have been therefore sought to improve stem cell survival and ensure long-term engraftment. In the present contribution, we show that embedding human cord blood-derived CD34(+) cells into a collagen I-based hydrogel containing cytokines is a suitable strategy to promote stem cell proliferation and protect these cells from anoxia-induced apoptosis. Hindawi Publishing Corporation 2013 2012-12-27 /pmc/articles/PMC3591191/ /pubmed/23509738 http://dx.doi.org/10.1155/2013/542810 Text en Copyright © 2013 Daniele Avitabile et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Avitabile, Daniele
Salchert, Katrin
Werner, Carsten
Capogrossi, Maurizio C.
Pesce, Maurizio
Growth Induction and Low-Oxygen Apoptosis Inhibition of Human CD34(+) Progenitors in Collagen Gels
title Growth Induction and Low-Oxygen Apoptosis Inhibition of Human CD34(+) Progenitors in Collagen Gels
title_full Growth Induction and Low-Oxygen Apoptosis Inhibition of Human CD34(+) Progenitors in Collagen Gels
title_fullStr Growth Induction and Low-Oxygen Apoptosis Inhibition of Human CD34(+) Progenitors in Collagen Gels
title_full_unstemmed Growth Induction and Low-Oxygen Apoptosis Inhibition of Human CD34(+) Progenitors in Collagen Gels
title_short Growth Induction and Low-Oxygen Apoptosis Inhibition of Human CD34(+) Progenitors in Collagen Gels
title_sort growth induction and low-oxygen apoptosis inhibition of human cd34(+) progenitors in collagen gels
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591191/
https://www.ncbi.nlm.nih.gov/pubmed/23509738
http://dx.doi.org/10.1155/2013/542810
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