Modulation of the Antibiotic Activity by Extracts from Amburana cearensis A. C. Smith and Anadenanthera macrocarpa (Benth.) Brenan

The aim of this study was to verify the possible interactions between ethanol extracts of Amburana cearensis A. C. Smith and Anadenanthera macrocarpa (Benth.) Brenan, combined with six antimicrobial drugs against multiresistant strains of Staphylococcus aureus and Escherichia coli isolated from huma...

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Autores principales: Figueredo, Fernando G., Ferreira, Emerson O., Lucena, Bruno F. F., Torres, Cícero M. G., Lucetti, Daniel L., Lucetti, Elaine C. P., Silva, João Marcos F. L., Santos, Francisco A. V., Medeiros, Cássio R., Oliveira, Gardênia M. M., Colares, Aracélio V., Costa, José G. M., Coutinho, Henrique D. M., Menezes, Irwin R. A., Silva, Júlio C. F., Kerntopf, Marta R., Figueiredo, Patrícia R. L., Matias, Edinardo F. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591201/
https://www.ncbi.nlm.nih.gov/pubmed/23509756
http://dx.doi.org/10.1155/2013/640682
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author Figueredo, Fernando G.
Ferreira, Emerson O.
Lucena, Bruno F. F.
Torres, Cícero M. G.
Lucetti, Daniel L.
Lucetti, Elaine C. P.
Silva, João Marcos F. L.
Santos, Francisco A. V.
Medeiros, Cássio R.
Oliveira, Gardênia M. M.
Colares, Aracélio V.
Costa, José G. M.
Coutinho, Henrique D. M.
Menezes, Irwin R. A.
Silva, Júlio C. F.
Kerntopf, Marta R.
Figueiredo, Patrícia R. L.
Matias, Edinardo F. F.
author_facet Figueredo, Fernando G.
Ferreira, Emerson O.
Lucena, Bruno F. F.
Torres, Cícero M. G.
Lucetti, Daniel L.
Lucetti, Elaine C. P.
Silva, João Marcos F. L.
Santos, Francisco A. V.
Medeiros, Cássio R.
Oliveira, Gardênia M. M.
Colares, Aracélio V.
Costa, José G. M.
Coutinho, Henrique D. M.
Menezes, Irwin R. A.
Silva, Júlio C. F.
Kerntopf, Marta R.
Figueiredo, Patrícia R. L.
Matias, Edinardo F. F.
author_sort Figueredo, Fernando G.
collection PubMed
description The aim of this study was to verify the possible interactions between ethanol extracts of Amburana cearensis A. C. Smith and Anadenanthera macrocarpa (Benth.) Brenan, combined with six antimicrobial drugs against multiresistant strains of Staphylococcus aureus and Escherichia coli isolated from humans. The antibacterial activity of the extracts was determined using the minimum inhibitory concentration (MIC). The microdilution assay was performed to verify the interactions between the natural products and the antibiotics using a subinhibitory concentration. The activity of amikacin associated with the extract of Anadenanthera macrocarpa against EC 27 was enhanced, demonstrating an MIC reduction from 128 to 4 μg/mL. Among the β-lactams, no potentiation on its activity was observed, with exception to the antagonism of the natural products with ampicillin against S. aureus 358.
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spelling pubmed-35912012013-03-18 Modulation of the Antibiotic Activity by Extracts from Amburana cearensis A. C. Smith and Anadenanthera macrocarpa (Benth.) Brenan Figueredo, Fernando G. Ferreira, Emerson O. Lucena, Bruno F. F. Torres, Cícero M. G. Lucetti, Daniel L. Lucetti, Elaine C. P. Silva, João Marcos F. L. Santos, Francisco A. V. Medeiros, Cássio R. Oliveira, Gardênia M. M. Colares, Aracélio V. Costa, José G. M. Coutinho, Henrique D. M. Menezes, Irwin R. A. Silva, Júlio C. F. Kerntopf, Marta R. Figueiredo, Patrícia R. L. Matias, Edinardo F. F. Biomed Res Int Research Article The aim of this study was to verify the possible interactions between ethanol extracts of Amburana cearensis A. C. Smith and Anadenanthera macrocarpa (Benth.) Brenan, combined with six antimicrobial drugs against multiresistant strains of Staphylococcus aureus and Escherichia coli isolated from humans. The antibacterial activity of the extracts was determined using the minimum inhibitory concentration (MIC). The microdilution assay was performed to verify the interactions between the natural products and the antibiotics using a subinhibitory concentration. The activity of amikacin associated with the extract of Anadenanthera macrocarpa against EC 27 was enhanced, demonstrating an MIC reduction from 128 to 4 μg/mL. Among the β-lactams, no potentiation on its activity was observed, with exception to the antagonism of the natural products with ampicillin against S. aureus 358. Hindawi Publishing Corporation 2013 2012-12-27 /pmc/articles/PMC3591201/ /pubmed/23509756 http://dx.doi.org/10.1155/2013/640682 Text en Copyright © 2013 Fernando G. Figueredo et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Figueredo, Fernando G.
Ferreira, Emerson O.
Lucena, Bruno F. F.
Torres, Cícero M. G.
Lucetti, Daniel L.
Lucetti, Elaine C. P.
Silva, João Marcos F. L.
Santos, Francisco A. V.
Medeiros, Cássio R.
Oliveira, Gardênia M. M.
Colares, Aracélio V.
Costa, José G. M.
Coutinho, Henrique D. M.
Menezes, Irwin R. A.
Silva, Júlio C. F.
Kerntopf, Marta R.
Figueiredo, Patrícia R. L.
Matias, Edinardo F. F.
Modulation of the Antibiotic Activity by Extracts from Amburana cearensis A. C. Smith and Anadenanthera macrocarpa (Benth.) Brenan
title Modulation of the Antibiotic Activity by Extracts from Amburana cearensis A. C. Smith and Anadenanthera macrocarpa (Benth.) Brenan
title_full Modulation of the Antibiotic Activity by Extracts from Amburana cearensis A. C. Smith and Anadenanthera macrocarpa (Benth.) Brenan
title_fullStr Modulation of the Antibiotic Activity by Extracts from Amburana cearensis A. C. Smith and Anadenanthera macrocarpa (Benth.) Brenan
title_full_unstemmed Modulation of the Antibiotic Activity by Extracts from Amburana cearensis A. C. Smith and Anadenanthera macrocarpa (Benth.) Brenan
title_short Modulation of the Antibiotic Activity by Extracts from Amburana cearensis A. C. Smith and Anadenanthera macrocarpa (Benth.) Brenan
title_sort modulation of the antibiotic activity by extracts from amburana cearensis a. c. smith and anadenanthera macrocarpa (benth.) brenan
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591201/
https://www.ncbi.nlm.nih.gov/pubmed/23509756
http://dx.doi.org/10.1155/2013/640682
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