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Effect of Nanoparticles and Environmental Particles on a Cocultures Model of the Air-Blood Barrier

Exposure to engineered nanoparticles (NPs) and to ambient particles (PM) has increased significantly. During the last decades the application of nano-objects to daily-life goods and the emissions produced in highly urbanized cities have considerably augmented. As a consequence, the understanding of...

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Detalles Bibliográficos
Autores principales: Bengalli, Rossella, Mantecca, Paride, Camatini, Marina, Gualtieri, Maurizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591223/
https://www.ncbi.nlm.nih.gov/pubmed/23509780
http://dx.doi.org/10.1155/2013/801214
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author Bengalli, Rossella
Mantecca, Paride
Camatini, Marina
Gualtieri, Maurizio
author_facet Bengalli, Rossella
Mantecca, Paride
Camatini, Marina
Gualtieri, Maurizio
author_sort Bengalli, Rossella
collection PubMed
description Exposure to engineered nanoparticles (NPs) and to ambient particles (PM) has increased significantly. During the last decades the application of nano-objects to daily-life goods and the emissions produced in highly urbanized cities have considerably augmented. As a consequence, the understanding of the possible effects of NPs and PM on human respiratory system and particularly on the air-blood barrier (ABB) has become of primary interest. The crosstalk between lung epithelial cells and underlying endothelial cells is indeed essential in determining the effects of inhaled particles. Here we report the effects of metal oxides NPs (CuO and TiO(2)) and of PM on an in vitro model of the ABB constituted by the type II epithelial cell line (NCI-H441) and the endothelial one (HPMEC-ST1.6R). The results demonstrate that apical exposure of alveolar cells induces significant modulation of proinflammatory proteins also in endothelial cells.
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spelling pubmed-35912232013-03-18 Effect of Nanoparticles and Environmental Particles on a Cocultures Model of the Air-Blood Barrier Bengalli, Rossella Mantecca, Paride Camatini, Marina Gualtieri, Maurizio Biomed Res Int Research Article Exposure to engineered nanoparticles (NPs) and to ambient particles (PM) has increased significantly. During the last decades the application of nano-objects to daily-life goods and the emissions produced in highly urbanized cities have considerably augmented. As a consequence, the understanding of the possible effects of NPs and PM on human respiratory system and particularly on the air-blood barrier (ABB) has become of primary interest. The crosstalk between lung epithelial cells and underlying endothelial cells is indeed essential in determining the effects of inhaled particles. Here we report the effects of metal oxides NPs (CuO and TiO(2)) and of PM on an in vitro model of the ABB constituted by the type II epithelial cell line (NCI-H441) and the endothelial one (HPMEC-ST1.6R). The results demonstrate that apical exposure of alveolar cells induces significant modulation of proinflammatory proteins also in endothelial cells. Hindawi Publishing Corporation 2013 2012-12-23 /pmc/articles/PMC3591223/ /pubmed/23509780 http://dx.doi.org/10.1155/2013/801214 Text en Copyright © 2013 Rossella Bengalli et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Bengalli, Rossella
Mantecca, Paride
Camatini, Marina
Gualtieri, Maurizio
Effect of Nanoparticles and Environmental Particles on a Cocultures Model of the Air-Blood Barrier
title Effect of Nanoparticles and Environmental Particles on a Cocultures Model of the Air-Blood Barrier
title_full Effect of Nanoparticles and Environmental Particles on a Cocultures Model of the Air-Blood Barrier
title_fullStr Effect of Nanoparticles and Environmental Particles on a Cocultures Model of the Air-Blood Barrier
title_full_unstemmed Effect of Nanoparticles and Environmental Particles on a Cocultures Model of the Air-Blood Barrier
title_short Effect of Nanoparticles and Environmental Particles on a Cocultures Model of the Air-Blood Barrier
title_sort effect of nanoparticles and environmental particles on a cocultures model of the air-blood barrier
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591223/
https://www.ncbi.nlm.nih.gov/pubmed/23509780
http://dx.doi.org/10.1155/2013/801214
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