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Chemical Composition and Antibacterial and Cytotoxic Activities of Allium hirtifolium Boiss

Allium hirtifolium Boiss. known as Persian shallot, is a spice used as a traditional medicine in Iran and, Mediterranean region. In this study, the chemical composition of the hydromethanolic extract of this plant was analyzed using GC/MS. The result showed that 9-hexadecenoic acid, 11,14-eicosadien...

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Autores principales: Ismail, Salmiah, Jalilian, Farid Azizi, Talebpour, Amir Hossein, Zargar, Mohsen, Shameli, Kamyar, Sekawi, Zamberi, Jahanshiri, Fatemeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591250/
https://www.ncbi.nlm.nih.gov/pubmed/23484141
http://dx.doi.org/10.1155/2013/696835
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author Ismail, Salmiah
Jalilian, Farid Azizi
Talebpour, Amir Hossein
Zargar, Mohsen
Shameli, Kamyar
Sekawi, Zamberi
Jahanshiri, Fatemeh
author_facet Ismail, Salmiah
Jalilian, Farid Azizi
Talebpour, Amir Hossein
Zargar, Mohsen
Shameli, Kamyar
Sekawi, Zamberi
Jahanshiri, Fatemeh
author_sort Ismail, Salmiah
collection PubMed
description Allium hirtifolium Boiss. known as Persian shallot, is a spice used as a traditional medicine in Iran and, Mediterranean region. In this study, the chemical composition of the hydromethanolic extract of this plant was analyzed using GC/MS. The result showed that 9-hexadecenoic acid, 11,14-eicosadienoic acid, and n-hexadecanoic acid are the main constituents. The antibacterial activity of the shallot extract was also examined by disk diffusion and microdilution broth assays. It was demonstrated that Persian shallot hydromethanolic extract was effective against 10 different species of pathogenic bacteria including methicillin resistant Staphylococcus aureus (MRSA), methicillin sensitive Staphylococcus aureus (MSSA), Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Escherichia coli, Escherichia coli O157:H7, Salmonella typhimurium, Proteus mirabilis, and Klebsiella pneumoniae. Specifically, the minimum concentration of the extract which inhibited bacterial growth (MIC values) was 1.88 mg/mL for most of the gram-positive bacteria. This concentration was not much different from the concentration that was safe for mammalian cells (1.50 mg/mL) suggesting that the hydromethanolic extract of Persian shallot may be a safe and strong antibacterial agent.
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spelling pubmed-35912502013-03-12 Chemical Composition and Antibacterial and Cytotoxic Activities of Allium hirtifolium Boiss Ismail, Salmiah Jalilian, Farid Azizi Talebpour, Amir Hossein Zargar, Mohsen Shameli, Kamyar Sekawi, Zamberi Jahanshiri, Fatemeh Biomed Res Int Research Article Allium hirtifolium Boiss. known as Persian shallot, is a spice used as a traditional medicine in Iran and, Mediterranean region. In this study, the chemical composition of the hydromethanolic extract of this plant was analyzed using GC/MS. The result showed that 9-hexadecenoic acid, 11,14-eicosadienoic acid, and n-hexadecanoic acid are the main constituents. The antibacterial activity of the shallot extract was also examined by disk diffusion and microdilution broth assays. It was demonstrated that Persian shallot hydromethanolic extract was effective against 10 different species of pathogenic bacteria including methicillin resistant Staphylococcus aureus (MRSA), methicillin sensitive Staphylococcus aureus (MSSA), Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Escherichia coli, Escherichia coli O157:H7, Salmonella typhimurium, Proteus mirabilis, and Klebsiella pneumoniae. Specifically, the minimum concentration of the extract which inhibited bacterial growth (MIC values) was 1.88 mg/mL for most of the gram-positive bacteria. This concentration was not much different from the concentration that was safe for mammalian cells (1.50 mg/mL) suggesting that the hydromethanolic extract of Persian shallot may be a safe and strong antibacterial agent. Hindawi Publishing Corporation 2013 2012-12-23 /pmc/articles/PMC3591250/ /pubmed/23484141 http://dx.doi.org/10.1155/2013/696835 Text en Copyright © 2013 Salmiah Ismail et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ismail, Salmiah
Jalilian, Farid Azizi
Talebpour, Amir Hossein
Zargar, Mohsen
Shameli, Kamyar
Sekawi, Zamberi
Jahanshiri, Fatemeh
Chemical Composition and Antibacterial and Cytotoxic Activities of Allium hirtifolium Boiss
title Chemical Composition and Antibacterial and Cytotoxic Activities of Allium hirtifolium Boiss
title_full Chemical Composition and Antibacterial and Cytotoxic Activities of Allium hirtifolium Boiss
title_fullStr Chemical Composition and Antibacterial and Cytotoxic Activities of Allium hirtifolium Boiss
title_full_unstemmed Chemical Composition and Antibacterial and Cytotoxic Activities of Allium hirtifolium Boiss
title_short Chemical Composition and Antibacterial and Cytotoxic Activities of Allium hirtifolium Boiss
title_sort chemical composition and antibacterial and cytotoxic activities of allium hirtifolium boiss
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591250/
https://www.ncbi.nlm.nih.gov/pubmed/23484141
http://dx.doi.org/10.1155/2013/696835
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