A gp41 MPER-specific Llama VHH Requires a Hydrophobic CDR3 for Neutralization but not for Antigen Recognition

The membrane proximal external region (MPER) of the HIV-1 glycoprotein gp41 is targeted by the broadly neutralizing antibodies 2F5 and 4E10. To date, no immunization regimen in animals or humans has produced HIV-1 neutralizing MPER-specific antibodies. We immunized llamas with gp41-MPER proteoliposo...

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Detalles Bibliográficos
Autores principales: Lutje Hulsik, David, Liu, Ying-ying, Strokappe, Nika M., Battella, Simone, El Khattabi, Mohamed, McCoy, Laura E., Sabin, Charles, Hinz, Andreas, Hock, Miriam, Macheboeuf, Pauline, Bonvin, Alexandre M. J. J., Langedijk, Johannes P. M., Davis, David, Forsman Quigley, Anna, Aasa-Chapman, Marlén M. I., Seaman, Michael S., Ramos, Alejandra, Poignard, Pascal, Favier, Adrien, Simorre, Jean-Pierre, Weiss, Robin A., Verrips, C. Theo, Weissenhorn, Winfried, Rutten, Lucy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591319/
https://www.ncbi.nlm.nih.gov/pubmed/23505368
http://dx.doi.org/10.1371/journal.ppat.1003202

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