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A Genome-Wide Analysis of Populations from European Russia Reveals a New Pole of Genetic Diversity in Northern Europe

Several studies examined the fine-scale structure of human genetic variation in Europe. However, the European sets analyzed represent mainly northern, western, central, and southern Europe. Here, we report an analysis of approximately 166,000 single nucleotide polymorphisms in populations from easte...

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Autores principales: Khrunin, Andrey V., Khokhrin, Denis V., Filippova, Irina N., Esko, Tõnu, Nelis, Mari, Bebyakova, Natalia A., Bolotova, Natalia L., Klovins, Janis, Nikitina-Zake, Liene, Rehnström, Karola, Ripatti, Samuli, Schreiber, Stefan, Franke, Andre, Macek, Milan, Krulišová, Veronika, Lubinski, Jan, Metspalu, Andres, Limborska, Svetlana A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591355/
https://www.ncbi.nlm.nih.gov/pubmed/23505534
http://dx.doi.org/10.1371/journal.pone.0058552
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author Khrunin, Andrey V.
Khokhrin, Denis V.
Filippova, Irina N.
Esko, Tõnu
Nelis, Mari
Bebyakova, Natalia A.
Bolotova, Natalia L.
Klovins, Janis
Nikitina-Zake, Liene
Rehnström, Karola
Ripatti, Samuli
Schreiber, Stefan
Franke, Andre
Macek, Milan
Krulišová, Veronika
Lubinski, Jan
Metspalu, Andres
Limborska, Svetlana A.
author_facet Khrunin, Andrey V.
Khokhrin, Denis V.
Filippova, Irina N.
Esko, Tõnu
Nelis, Mari
Bebyakova, Natalia A.
Bolotova, Natalia L.
Klovins, Janis
Nikitina-Zake, Liene
Rehnström, Karola
Ripatti, Samuli
Schreiber, Stefan
Franke, Andre
Macek, Milan
Krulišová, Veronika
Lubinski, Jan
Metspalu, Andres
Limborska, Svetlana A.
author_sort Khrunin, Andrey V.
collection PubMed
description Several studies examined the fine-scale structure of human genetic variation in Europe. However, the European sets analyzed represent mainly northern, western, central, and southern Europe. Here, we report an analysis of approximately 166,000 single nucleotide polymorphisms in populations from eastern (northeastern) Europe: four Russian populations from European Russia, and three populations from the northernmost Finno-Ugric ethnicities (Veps and two contrast groups of Komi people). These were compared with several reference European samples, including Finns, Estonians, Latvians, Poles, Czechs, Germans, and Italians. The results obtained demonstrated genetic heterogeneity of populations living in the region studied. Russians from the central part of European Russia (Tver, Murom, and Kursk) exhibited similarities with populations from central–eastern Europe, and were distant from Russian sample from the northern Russia (Mezen district, Archangelsk region). Komi samples, especially Izhemski Komi, were significantly different from all other populations studied. These can be considered as a second pole of genetic diversity in northern Europe (in addition to the pole, occupied by Finns), as they had a distinct ancestry component. Russians from Mezen and the Finnic-speaking Veps were positioned between the two poles, but differed from each other in the proportions of Komi and Finnic ancestries. In general, our data provides a more complete genetic map of Europe accounting for the diversity in its most eastern (northeastern) populations.
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spelling pubmed-35913552013-03-15 A Genome-Wide Analysis of Populations from European Russia Reveals a New Pole of Genetic Diversity in Northern Europe Khrunin, Andrey V. Khokhrin, Denis V. Filippova, Irina N. Esko, Tõnu Nelis, Mari Bebyakova, Natalia A. Bolotova, Natalia L. Klovins, Janis Nikitina-Zake, Liene Rehnström, Karola Ripatti, Samuli Schreiber, Stefan Franke, Andre Macek, Milan Krulišová, Veronika Lubinski, Jan Metspalu, Andres Limborska, Svetlana A. PLoS One Research Article Several studies examined the fine-scale structure of human genetic variation in Europe. However, the European sets analyzed represent mainly northern, western, central, and southern Europe. Here, we report an analysis of approximately 166,000 single nucleotide polymorphisms in populations from eastern (northeastern) Europe: four Russian populations from European Russia, and three populations from the northernmost Finno-Ugric ethnicities (Veps and two contrast groups of Komi people). These were compared with several reference European samples, including Finns, Estonians, Latvians, Poles, Czechs, Germans, and Italians. The results obtained demonstrated genetic heterogeneity of populations living in the region studied. Russians from the central part of European Russia (Tver, Murom, and Kursk) exhibited similarities with populations from central–eastern Europe, and were distant from Russian sample from the northern Russia (Mezen district, Archangelsk region). Komi samples, especially Izhemski Komi, were significantly different from all other populations studied. These can be considered as a second pole of genetic diversity in northern Europe (in addition to the pole, occupied by Finns), as they had a distinct ancestry component. Russians from Mezen and the Finnic-speaking Veps were positioned between the two poles, but differed from each other in the proportions of Komi and Finnic ancestries. In general, our data provides a more complete genetic map of Europe accounting for the diversity in its most eastern (northeastern) populations. Public Library of Science 2013-03-07 /pmc/articles/PMC3591355/ /pubmed/23505534 http://dx.doi.org/10.1371/journal.pone.0058552 Text en © 2013 Khrunin et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Khrunin, Andrey V.
Khokhrin, Denis V.
Filippova, Irina N.
Esko, Tõnu
Nelis, Mari
Bebyakova, Natalia A.
Bolotova, Natalia L.
Klovins, Janis
Nikitina-Zake, Liene
Rehnström, Karola
Ripatti, Samuli
Schreiber, Stefan
Franke, Andre
Macek, Milan
Krulišová, Veronika
Lubinski, Jan
Metspalu, Andres
Limborska, Svetlana A.
A Genome-Wide Analysis of Populations from European Russia Reveals a New Pole of Genetic Diversity in Northern Europe
title A Genome-Wide Analysis of Populations from European Russia Reveals a New Pole of Genetic Diversity in Northern Europe
title_full A Genome-Wide Analysis of Populations from European Russia Reveals a New Pole of Genetic Diversity in Northern Europe
title_fullStr A Genome-Wide Analysis of Populations from European Russia Reveals a New Pole of Genetic Diversity in Northern Europe
title_full_unstemmed A Genome-Wide Analysis of Populations from European Russia Reveals a New Pole of Genetic Diversity in Northern Europe
title_short A Genome-Wide Analysis of Populations from European Russia Reveals a New Pole of Genetic Diversity in Northern Europe
title_sort genome-wide analysis of populations from european russia reveals a new pole of genetic diversity in northern europe
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591355/
https://www.ncbi.nlm.nih.gov/pubmed/23505534
http://dx.doi.org/10.1371/journal.pone.0058552
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