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Replication Study Confirms Link between TSPAN18 Mutation and Schizophrenia in Han Chinese

Schizophrenia (SCZ) is a severe psychiatric disorder associated with many different risk factors, both genetic and environmental. A recent genome-wide association study (GWAS) of Han Chinese identified three single-nucleotide polymorphisms (SNPs rs11038167, rs11038172, and rs835784) in the tetraspan...

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Autores principales: Yuan, Jianmin, Jin, Chunhui, Qin, Hai-De, Wang, Jidong, Sha, Weiwei, Wang, Mingzhong, Zhang, Yunbiao, Zhang, Fuquan, Li, Jijiang, Li, Jianfeng, Yu, Shui, Qi, Shuguang, Shugart, Yin Yao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591373/
https://www.ncbi.nlm.nih.gov/pubmed/23505562
http://dx.doi.org/10.1371/journal.pone.0058785
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author Yuan, Jianmin
Jin, Chunhui
Qin, Hai-De
Wang, Jidong
Sha, Weiwei
Wang, Mingzhong
Zhang, Yunbiao
Zhang, Fuquan
Li, Jijiang
Li, Jianfeng
Yu, Shui
Qi, Shuguang
Shugart, Yin Yao
author_facet Yuan, Jianmin
Jin, Chunhui
Qin, Hai-De
Wang, Jidong
Sha, Weiwei
Wang, Mingzhong
Zhang, Yunbiao
Zhang, Fuquan
Li, Jijiang
Li, Jianfeng
Yu, Shui
Qi, Shuguang
Shugart, Yin Yao
author_sort Yuan, Jianmin
collection PubMed
description Schizophrenia (SCZ) is a severe psychiatric disorder associated with many different risk factors, both genetic and environmental. A recent genome-wide association study (GWAS) of Han Chinese identified three single-nucleotide polymorphisms (SNPs rs11038167, rs11038172, and rs835784) in the tetraspanins gene TSPAN18 as possible susceptibility loci for schizophrenia. Hoping to validate these findings, we conducted a case-control study of Han Chinese with 1093 schizophrenia cases and 1022 healthy controls. Using the LDR-PCR method to genotype polymorphisms in TSPAN18, we found no significant differences (P>0.05) between patients and controls in either the allele or genotype frequency of the SNPs rs11038167 and rs11038172. We did find, however, that the frequency of the ‘A’ allele of SNP rs835784 is significantly higher in patients than in controls. We further observed a significant association (OR  = 1.197, 95%CI  = 1.047–1.369) between risk for SCZ and this ‘A’ allele. These results confirm the significant association, in Han Chinese populations, of increased SCZ risk and the variant of the TSPAN18 gene containing the ‘A’ allele of SNP rs835784.
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spelling pubmed-35913732013-03-15 Replication Study Confirms Link between TSPAN18 Mutation and Schizophrenia in Han Chinese Yuan, Jianmin Jin, Chunhui Qin, Hai-De Wang, Jidong Sha, Weiwei Wang, Mingzhong Zhang, Yunbiao Zhang, Fuquan Li, Jijiang Li, Jianfeng Yu, Shui Qi, Shuguang Shugart, Yin Yao PLoS One Research Article Schizophrenia (SCZ) is a severe psychiatric disorder associated with many different risk factors, both genetic and environmental. A recent genome-wide association study (GWAS) of Han Chinese identified three single-nucleotide polymorphisms (SNPs rs11038167, rs11038172, and rs835784) in the tetraspanins gene TSPAN18 as possible susceptibility loci for schizophrenia. Hoping to validate these findings, we conducted a case-control study of Han Chinese with 1093 schizophrenia cases and 1022 healthy controls. Using the LDR-PCR method to genotype polymorphisms in TSPAN18, we found no significant differences (P>0.05) between patients and controls in either the allele or genotype frequency of the SNPs rs11038167 and rs11038172. We did find, however, that the frequency of the ‘A’ allele of SNP rs835784 is significantly higher in patients than in controls. We further observed a significant association (OR  = 1.197, 95%CI  = 1.047–1.369) between risk for SCZ and this ‘A’ allele. These results confirm the significant association, in Han Chinese populations, of increased SCZ risk and the variant of the TSPAN18 gene containing the ‘A’ allele of SNP rs835784. Public Library of Science 2013-03-07 /pmc/articles/PMC3591373/ /pubmed/23505562 http://dx.doi.org/10.1371/journal.pone.0058785 Text en https://creativecommons.org/publicdomain/zero/1.0/ This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.
spellingShingle Research Article
Yuan, Jianmin
Jin, Chunhui
Qin, Hai-De
Wang, Jidong
Sha, Weiwei
Wang, Mingzhong
Zhang, Yunbiao
Zhang, Fuquan
Li, Jijiang
Li, Jianfeng
Yu, Shui
Qi, Shuguang
Shugart, Yin Yao
Replication Study Confirms Link between TSPAN18 Mutation and Schizophrenia in Han Chinese
title Replication Study Confirms Link between TSPAN18 Mutation and Schizophrenia in Han Chinese
title_full Replication Study Confirms Link between TSPAN18 Mutation and Schizophrenia in Han Chinese
title_fullStr Replication Study Confirms Link between TSPAN18 Mutation and Schizophrenia in Han Chinese
title_full_unstemmed Replication Study Confirms Link between TSPAN18 Mutation and Schizophrenia in Han Chinese
title_short Replication Study Confirms Link between TSPAN18 Mutation and Schizophrenia in Han Chinese
title_sort replication study confirms link between tspan18 mutation and schizophrenia in han chinese
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591373/
https://www.ncbi.nlm.nih.gov/pubmed/23505562
http://dx.doi.org/10.1371/journal.pone.0058785
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