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Replication Study Confirms Link between TSPAN18 Mutation and Schizophrenia in Han Chinese
Schizophrenia (SCZ) is a severe psychiatric disorder associated with many different risk factors, both genetic and environmental. A recent genome-wide association study (GWAS) of Han Chinese identified three single-nucleotide polymorphisms (SNPs rs11038167, rs11038172, and rs835784) in the tetraspan...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591373/ https://www.ncbi.nlm.nih.gov/pubmed/23505562 http://dx.doi.org/10.1371/journal.pone.0058785 |
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author | Yuan, Jianmin Jin, Chunhui Qin, Hai-De Wang, Jidong Sha, Weiwei Wang, Mingzhong Zhang, Yunbiao Zhang, Fuquan Li, Jijiang Li, Jianfeng Yu, Shui Qi, Shuguang Shugart, Yin Yao |
author_facet | Yuan, Jianmin Jin, Chunhui Qin, Hai-De Wang, Jidong Sha, Weiwei Wang, Mingzhong Zhang, Yunbiao Zhang, Fuquan Li, Jijiang Li, Jianfeng Yu, Shui Qi, Shuguang Shugart, Yin Yao |
author_sort | Yuan, Jianmin |
collection | PubMed |
description | Schizophrenia (SCZ) is a severe psychiatric disorder associated with many different risk factors, both genetic and environmental. A recent genome-wide association study (GWAS) of Han Chinese identified three single-nucleotide polymorphisms (SNPs rs11038167, rs11038172, and rs835784) in the tetraspanins gene TSPAN18 as possible susceptibility loci for schizophrenia. Hoping to validate these findings, we conducted a case-control study of Han Chinese with 1093 schizophrenia cases and 1022 healthy controls. Using the LDR-PCR method to genotype polymorphisms in TSPAN18, we found no significant differences (P>0.05) between patients and controls in either the allele or genotype frequency of the SNPs rs11038167 and rs11038172. We did find, however, that the frequency of the ‘A’ allele of SNP rs835784 is significantly higher in patients than in controls. We further observed a significant association (OR = 1.197, 95%CI = 1.047–1.369) between risk for SCZ and this ‘A’ allele. These results confirm the significant association, in Han Chinese populations, of increased SCZ risk and the variant of the TSPAN18 gene containing the ‘A’ allele of SNP rs835784. |
format | Online Article Text |
id | pubmed-3591373 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-35913732013-03-15 Replication Study Confirms Link between TSPAN18 Mutation and Schizophrenia in Han Chinese Yuan, Jianmin Jin, Chunhui Qin, Hai-De Wang, Jidong Sha, Weiwei Wang, Mingzhong Zhang, Yunbiao Zhang, Fuquan Li, Jijiang Li, Jianfeng Yu, Shui Qi, Shuguang Shugart, Yin Yao PLoS One Research Article Schizophrenia (SCZ) is a severe psychiatric disorder associated with many different risk factors, both genetic and environmental. A recent genome-wide association study (GWAS) of Han Chinese identified three single-nucleotide polymorphisms (SNPs rs11038167, rs11038172, and rs835784) in the tetraspanins gene TSPAN18 as possible susceptibility loci for schizophrenia. Hoping to validate these findings, we conducted a case-control study of Han Chinese with 1093 schizophrenia cases and 1022 healthy controls. Using the LDR-PCR method to genotype polymorphisms in TSPAN18, we found no significant differences (P>0.05) between patients and controls in either the allele or genotype frequency of the SNPs rs11038167 and rs11038172. We did find, however, that the frequency of the ‘A’ allele of SNP rs835784 is significantly higher in patients than in controls. We further observed a significant association (OR = 1.197, 95%CI = 1.047–1.369) between risk for SCZ and this ‘A’ allele. These results confirm the significant association, in Han Chinese populations, of increased SCZ risk and the variant of the TSPAN18 gene containing the ‘A’ allele of SNP rs835784. Public Library of Science 2013-03-07 /pmc/articles/PMC3591373/ /pubmed/23505562 http://dx.doi.org/10.1371/journal.pone.0058785 Text en https://creativecommons.org/publicdomain/zero/1.0/ This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. |
spellingShingle | Research Article Yuan, Jianmin Jin, Chunhui Qin, Hai-De Wang, Jidong Sha, Weiwei Wang, Mingzhong Zhang, Yunbiao Zhang, Fuquan Li, Jijiang Li, Jianfeng Yu, Shui Qi, Shuguang Shugart, Yin Yao Replication Study Confirms Link between TSPAN18 Mutation and Schizophrenia in Han Chinese |
title | Replication Study Confirms Link between TSPAN18 Mutation and Schizophrenia in Han Chinese |
title_full | Replication Study Confirms Link between TSPAN18 Mutation and Schizophrenia in Han Chinese |
title_fullStr | Replication Study Confirms Link between TSPAN18 Mutation and Schizophrenia in Han Chinese |
title_full_unstemmed | Replication Study Confirms Link between TSPAN18 Mutation and Schizophrenia in Han Chinese |
title_short | Replication Study Confirms Link between TSPAN18 Mutation and Schizophrenia in Han Chinese |
title_sort | replication study confirms link between tspan18 mutation and schizophrenia in han chinese |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591373/ https://www.ncbi.nlm.nih.gov/pubmed/23505562 http://dx.doi.org/10.1371/journal.pone.0058785 |
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