In Vivo Knockdown of TAK1 Accelerates Bone Marrow Proliferation/Differentiation and Induces Systemic Inflammation

TAK1 (TGF-β Activated Kinase 1) is a MAPK kinase kinase, which activates the p38- and JNK-MAPK and NF-κB pathways downstream of receptors such as Toll-Like-, cytokine- and T-cell and B-cell receptors. Representing such an important node in the pro-inflammatory signal-transduction network, the functi...

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Detalles Bibliográficos
Autores principales: Vink, Paul M., Smout, Wendy M., Driessen-Engels, Lilian J., de Bruin, Alex M., Delsing, Dianne, Krajnc-Franken, Magda A., Jansen, Aswin J., Rovers, Eric F., van Puijenbroek, André A., Kaptein, Allard, Nolte, Martijn A., Garritsen, Anja, van Eenennaam, Hans
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591390/
https://www.ncbi.nlm.nih.gov/pubmed/23505428
http://dx.doi.org/10.1371/journal.pone.0057348

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591390/
https://www.ncbi.nlm.nih.gov/pubmed/23505428
http://dx.doi.org/10.1371/journal.pone.0057348

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