Cytoplasmic Location of α1A Voltage-Gated Calcium Channel C-Terminal Fragment (Ca(v)2.1-CTF) Aggregate Is Sufficient to Cause Cell Death

The human α(1A) voltage-dependent calcium channel (Ca(v)2.1) is a pore-forming essential subunit embedded in the plasma membrane. Its cytoplasmic carboxyl(C)-tail contains a small poly-glutamine (Q) tract, whose length is normally 4∼19 Q, but when expanded up to 20∼33Q, the tract causes an autosomal...

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Detalles Bibliográficos
Autores principales: Takahashi, Makoto, Obayashi, Masato, Ishiguro, Taro, Sato, Nozomu, Niimi, Yusuke, Ozaki, Kokoro, Mogushi, Kaoru, Mahmut, Yasen, Tanaka, Hiroshi, Tsuruta, Fuminori, Dolmetsch, Ricardo, Yamada, Mitsunori, Takahashi, Hitoshi, Kato, Takeo, Mori, Osamu, Eishi, Yoshinobu, Mizusawa, Hidehiro, Ishikawa, Kinya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591409/
https://www.ncbi.nlm.nih.gov/pubmed/23505410
http://dx.doi.org/10.1371/journal.pone.0050121

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