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Association between Schizophrenia and Urinary Calculi: A Population-Based Case-Control Study
BACKGROUND: People with schizophrenia have been demonstrated to have higher overall morbidity and all-cause mortality rates from general medical conditions. However, little attention has been given to the urinary system of people with schizophrenia. As no direct evidence has been reported demonstrat...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591426/ https://www.ncbi.nlm.nih.gov/pubmed/23505416 http://dx.doi.org/10.1371/journal.pone.0056942 |
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author | Liu, Shih-Ping Lin, Ching-Chun Lin, Herng-Ching Chen, Yi-Hua Yu, Hong-Jeng |
author_facet | Liu, Shih-Ping Lin, Ching-Chun Lin, Herng-Ching Chen, Yi-Hua Yu, Hong-Jeng |
author_sort | Liu, Shih-Ping |
collection | PubMed |
description | BACKGROUND: People with schizophrenia have been demonstrated to have higher overall morbidity and all-cause mortality rates from general medical conditions. However, little attention has been given to the urinary system of people with schizophrenia. As no direct evidence has been reported demonstrating a link between schizophrenia and urinary calculi, this study utilized a population-based case-control study design to investigate the possibility of an association between schizophrenia and the occurrence of urinary calculi. METHOD: This study used data from the Taiwan Longitudinal Health Insurance Database. Cases consisted of 53,965 urinary calculi patients newly diagnosed between 2002 and 2008. In total, 269,825 controls were randomly selected and matched with the cases in terms of age and sex. Each person was traced to discern whether he had previously received a diagnosis of schizophrenia. Conditional logistic regression models were performed for the analysis. RESULTS: A total of 3,119 (1.0%) subjects had been diagnosed with schizophrenia prior to the index date. This included 0.7% of the patients with urinary calculi, and 1.0% of the controls. A prior diagnosis of schizophrenia was independently associated with a 30% decrease (95% CI = 0.62–0.76) in the occurrence of urinary calculi. The reduction was even more remarkable in males (38%, 95% CI = 0.55–0.71) and in elder individuals independent of gender (48% in those aged >69, 95% CI = 0.36–0.77). CONCLUSION: Our findings suggest that there is an inverse association between schizophrenia and urinary calculi. Future studies are needed to elucidate the mechanisms by which schizophrenia negatively associates with urinary calculi. |
format | Online Article Text |
id | pubmed-3591426 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-35914262013-03-15 Association between Schizophrenia and Urinary Calculi: A Population-Based Case-Control Study Liu, Shih-Ping Lin, Ching-Chun Lin, Herng-Ching Chen, Yi-Hua Yu, Hong-Jeng PLoS One Research Article BACKGROUND: People with schizophrenia have been demonstrated to have higher overall morbidity and all-cause mortality rates from general medical conditions. However, little attention has been given to the urinary system of people with schizophrenia. As no direct evidence has been reported demonstrating a link between schizophrenia and urinary calculi, this study utilized a population-based case-control study design to investigate the possibility of an association between schizophrenia and the occurrence of urinary calculi. METHOD: This study used data from the Taiwan Longitudinal Health Insurance Database. Cases consisted of 53,965 urinary calculi patients newly diagnosed between 2002 and 2008. In total, 269,825 controls were randomly selected and matched with the cases in terms of age and sex. Each person was traced to discern whether he had previously received a diagnosis of schizophrenia. Conditional logistic regression models were performed for the analysis. RESULTS: A total of 3,119 (1.0%) subjects had been diagnosed with schizophrenia prior to the index date. This included 0.7% of the patients with urinary calculi, and 1.0% of the controls. A prior diagnosis of schizophrenia was independently associated with a 30% decrease (95% CI = 0.62–0.76) in the occurrence of urinary calculi. The reduction was even more remarkable in males (38%, 95% CI = 0.55–0.71) and in elder individuals independent of gender (48% in those aged >69, 95% CI = 0.36–0.77). CONCLUSION: Our findings suggest that there is an inverse association between schizophrenia and urinary calculi. Future studies are needed to elucidate the mechanisms by which schizophrenia negatively associates with urinary calculi. Public Library of Science 2013-03-07 /pmc/articles/PMC3591426/ /pubmed/23505416 http://dx.doi.org/10.1371/journal.pone.0056942 Text en © 2013 Liu et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Liu, Shih-Ping Lin, Ching-Chun Lin, Herng-Ching Chen, Yi-Hua Yu, Hong-Jeng Association between Schizophrenia and Urinary Calculi: A Population-Based Case-Control Study |
title | Association between Schizophrenia and Urinary Calculi: A Population-Based Case-Control Study |
title_full | Association between Schizophrenia and Urinary Calculi: A Population-Based Case-Control Study |
title_fullStr | Association between Schizophrenia and Urinary Calculi: A Population-Based Case-Control Study |
title_full_unstemmed | Association between Schizophrenia and Urinary Calculi: A Population-Based Case-Control Study |
title_short | Association between Schizophrenia and Urinary Calculi: A Population-Based Case-Control Study |
title_sort | association between schizophrenia and urinary calculi: a population-based case-control study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591426/ https://www.ncbi.nlm.nih.gov/pubmed/23505416 http://dx.doi.org/10.1371/journal.pone.0056942 |
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