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The N-terminal Helix Controls the Transition between the Soluble and Amyloid States of an FF Domain
BACKGROUND: Protein aggregation is linked to the onset of an increasing number of human nonneuropathic (either localized or systemic) and neurodegenerative disorders. In particular, misfolding of native α-helical structures and their self-assembly into nonnative intermolecular β-sheets has been prop...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591442/ https://www.ncbi.nlm.nih.gov/pubmed/23505482 http://dx.doi.org/10.1371/journal.pone.0058297 |