Targeting the DNA-binding activity of the human ERG transcription factor using new heterocyclic dithiophene diamidines

Direct modulation of gene expression by targeting oncogenic transcription factors is a new area of research for cancer treatment. ERG, an ETS-family transcription factor, is commonly over-expressed or translocated in leukaemia and prostate carcinoma. In this work, we selected the di-(thiophene-pheny...

Descripción completa

Detalles Bibliográficos
Autores principales: Nhili, Raja, Peixoto, Paul, Depauw, Sabine, Flajollet, Sébastien, Dezitter, Xavier, Munde, Manoj M., Ismail, Mohamed A., Kumar, Arvind, Farahat, Abdelbasset A., Stephens, Chad E., Duterque-Coquillaud, Martine, David Wilson, W., Boykin, David W., David-Cordonnier, Marie-Hélène
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3592449/
https://www.ncbi.nlm.nih.gov/pubmed/23093599
http://dx.doi.org/10.1093/nar/gks971

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3592449/
https://www.ncbi.nlm.nih.gov/pubmed/23093599
http://dx.doi.org/10.1093/nar/gks971

Ejemplares similares