The crystal structure of human telomeric DNA complexed with berberine: an interesting case of stacked ligand to G-tetrad ratio higher than 1:1

The first crystal structure of human telomeric DNA in complex with the natural alkaloid berberine, produced by different plant families and used in folk medicine for millennia, was solved by X-ray diffraction method. The G-quadruplex unit features all-parallel strands. The overall folding assumed by...

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Detalles Bibliográficos
Autores principales: Bazzicalupi, Carla, Ferraroni, Marta, Bilia, Anna Rita, Scheggi, Francesca, Gratteri, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3592469/
https://www.ncbi.nlm.nih.gov/pubmed/23104378
http://dx.doi.org/10.1093/nar/gks1001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3592469/
https://www.ncbi.nlm.nih.gov/pubmed/23104378
http://dx.doi.org/10.1093/nar/gks1001

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