The Proton-Pump Inhibitor Lansoprazole Enhances Amyloid Beta Production

A key event in the pathogenesis of Alzheimer’s disease (AD) is the accumulation of amyloid-β (Aβ) species in the brain, derived from the sequential cleavage of the amyloid precursor protein (APP) by β- and γ-secretases. Based on a systems biology study to repurpose drugs for AD, we explore the effec...

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Detalles Bibliográficos
Autores principales: Badiola, Nahuai, Alcalde, Victor, Pujol, Albert, Münter, Lisa-Marie, Multhaup, Gerd, Lleó, Alberto, Coma, Mireia, Soler-López, Montserrat, Aloy, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3592824/
https://www.ncbi.nlm.nih.gov/pubmed/23520537
http://dx.doi.org/10.1371/journal.pone.0058837

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3592824/
https://www.ncbi.nlm.nih.gov/pubmed/23520537
http://dx.doi.org/10.1371/journal.pone.0058837

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