The Polo-Like Kinase 1 (PLK1) Inhibitor NMS-P937 Is Effective in a New Model of Disseminated Primary CD56(+) Acute Monoblastic Leukaemia

CD56 is expressed in 15–20% of acute myeloid leukaemias (AML) and is associated with extramedullary diffusion, multidrug resistance and poor prognosis. We describe the establishment and characterisation of a novel disseminated model of AML (AML-NS8), generated by injection into mice of leukaemic bla...

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Detalles Bibliográficos
Autores principales: Casolaro, Alessia, Golay, Josee, Albanese, Clara, Ceruti, Roberta, Patton, Veronica, Cribioli, Sabrina, Pezzoni, Alice, Losa, Marco, Texido, Gemma, Giussani, Ursula, Marchesi, Francesco, Amboldi, Nadia, Valsasina, Barbara, Bungaro, Silvia, Cazzaniga, Gianni, Rambaldi, Alessandro, Introna, Martino, Pesenti, Enrico, Alzani, Rachele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3592825/
https://www.ncbi.nlm.nih.gov/pubmed/23520509
http://dx.doi.org/10.1371/journal.pone.0058424

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