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Time- and residue-specific differences in histone acetylation induced by VPA and SAHA in AML1/ETO-positive leukemia cells

We analyzed the activity of the histone deacetylase inhibitor (HDACi) suberoyl-anilide hydroxamic acid (SAHA) on Kasumi-1 acute myeloid leukemia (AML) cells expressing AML1/ETO. We also compared the effects of SAHA to those of valproic acid (VPA), a short-chain fatty acid HDACi. SAHA and VPA induced...

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Detalles Bibliográficos
Autores principales:	Barbetti, Valentina, Gozzini, Antonella, Cheloni, Giulia, Marzi, Ilaria, Fabiani, Emiliano, Santini, Valeria, Dello Sbarba, Persio, Rovida, Elisabetta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Landes Bioscience 2013
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3592907/ https://www.ncbi.nlm.nih.gov/pubmed/23321683 http://dx.doi.org/10.4161/epi.23538

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