Intrahepatic Cholestasis of Pregnancy Levels of Sulfated Progesterone Metabolites Inhibit Farnesoid X Receptor Resulting in a Cholestatic Phenotype

Intrahepatic cholestasis of pregnancy (ICP) is the most prevalent pregnancy-specific liver disease and is associated with an increased risk of adverse fetal outcomes, including preterm labor and intrauterine death. The endocrine signals that cause cholestasis are not known but 3α-sulfated progestero...

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Detalles Bibliográficos
Autores principales: Abu-Hayyeh, Shadi, Papacleovoulou, Georgia, Lövgren-Sandblom, Anita, Tahir, Mehreen, Oduwole, Olayiwola, Jamaludin, Nurul Akmal, Ravat, Sabiha, Nikolova, Vanya, Chambers, Jenny, Selden, Clare, Rees, Myrddin, Marschall, Hanns-Ulrich, Parker, Malcolm G, Williamson, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Subscription Services, Inc., A Wiley Company 2013
Materias:
Autoimmune, Cholestatic and Biliary Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3592994/
https://www.ncbi.nlm.nih.gov/pubmed/22961653
http://dx.doi.org/10.1002/hep.26055

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