The reactivity of α-oxoaldehyde with reactive oxygen species in diabetes complications

The reactions of three α-oxoaldehydes (methylglyoxal, glyoxal, and pyruvic acid) with hydroxyl radicals generated by sonolysis of water were investigated using an electron spin resonance (electron paramagnetic resonance) spin-trapping method, and their reaction kinetics were investigated. It is appa...

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Detalles Bibliográficos
Autores principales: Matsumura, Yuriko, Iwasawa, Atsuo, Kobayashi, Toshihiro, Kamachi, Toshiaki, Ozawa, Toshihiko, Kohno, Masahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: the Society for Free Radical Research Japan 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3593129/
https://www.ncbi.nlm.nih.gov/pubmed/23526048
http://dx.doi.org/10.3164/jcbn.12-70
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author Matsumura, Yuriko
Iwasawa, Atsuo
Kobayashi, Toshihiro
Kamachi, Toshiaki
Ozawa, Toshihiko
Kohno, Masahiro
author_facet Matsumura, Yuriko
Iwasawa, Atsuo
Kobayashi, Toshihiro
Kamachi, Toshiaki
Ozawa, Toshihiko
Kohno, Masahiro
author_sort Matsumura, Yuriko
collection PubMed
description The reactions of three α-oxoaldehydes (methylglyoxal, glyoxal, and pyruvic acid) with hydroxyl radicals generated by sonolysis of water were investigated using an electron spin resonance (electron paramagnetic resonance) spin-trapping method, and their reaction kinetics were investigated. It is apparent from our experimental results that methylglyoxal exhibits the highest reactivity of the three α-oxoaldehydes. These α-oxoaldehydes can react with hydroxyl radicals faster than other well-known antioxidants can. The reactivity of hydroxyl radicals is higher than that of hydrogen peroxides.
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spelling pubmed-35931292013-03-22 The reactivity of α-oxoaldehyde with reactive oxygen species in diabetes complications Matsumura, Yuriko Iwasawa, Atsuo Kobayashi, Toshihiro Kamachi, Toshiaki Ozawa, Toshihiko Kohno, Masahiro J Clin Biochem Nutr Original Article The reactions of three α-oxoaldehydes (methylglyoxal, glyoxal, and pyruvic acid) with hydroxyl radicals generated by sonolysis of water were investigated using an electron spin resonance (electron paramagnetic resonance) spin-trapping method, and their reaction kinetics were investigated. It is apparent from our experimental results that methylglyoxal exhibits the highest reactivity of the three α-oxoaldehydes. These α-oxoaldehydes can react with hydroxyl radicals faster than other well-known antioxidants can. The reactivity of hydroxyl radicals is higher than that of hydrogen peroxides. the Society for Free Radical Research Japan 2013-03 2013-03-01 /pmc/articles/PMC3593129/ /pubmed/23526048 http://dx.doi.org/10.3164/jcbn.12-70 Text en Copyright © 2013 JCBN This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Matsumura, Yuriko
Iwasawa, Atsuo
Kobayashi, Toshihiro
Kamachi, Toshiaki
Ozawa, Toshihiko
Kohno, Masahiro
The reactivity of α-oxoaldehyde with reactive oxygen species in diabetes complications
title The reactivity of α-oxoaldehyde with reactive oxygen species in diabetes complications
title_full The reactivity of α-oxoaldehyde with reactive oxygen species in diabetes complications
title_fullStr The reactivity of α-oxoaldehyde with reactive oxygen species in diabetes complications
title_full_unstemmed The reactivity of α-oxoaldehyde with reactive oxygen species in diabetes complications
title_short The reactivity of α-oxoaldehyde with reactive oxygen species in diabetes complications
title_sort reactivity of α-oxoaldehyde with reactive oxygen species in diabetes complications
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3593129/
https://www.ncbi.nlm.nih.gov/pubmed/23526048
http://dx.doi.org/10.3164/jcbn.12-70
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