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Chemical and Structural Analysis of an Antibody Folding Intermediate Trapped during Glycan Biosynthesis

[Image: see text] Human IgG Fc glycosylation modulates immunological effector functions such as antibody-dependent cellular cytotoxicity and phagocytosis. Engineering of Fc glycans therefore enables fine-tuning of the therapeutic properties of monoclonal antibodies. The N-linked glycans of Fc are ty...

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Detalles Bibliográficos
Autores principales:	Bowden, Thomas A., Baruah, Kavitha, Coles, Charlotte H., Harvey, David J., Yu, Xiaojie, Song, Byeong-Doo, Stuart, David I., Aricescu, A. Radu, Scanlan, Christopher N., Jones, E. Yvonne, Crispin, Max
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2012
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3593610/ https://www.ncbi.nlm.nih.gov/pubmed/23025485 http://dx.doi.org/10.1021/ja306068g

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