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A synthetic superoxide dismutase/catalase mimetic EUK-207 mitigates radiation dermatitis and promotes wound healing in irradiated rat skin
In the event of a radionuclear attack or nuclear accident, the skin would be the first barrier exposed to radiation, though skin injury can progress over days to years following exposure. Chronic oxidative stress has been implicated as being a potential contributor to the progression of delayed radi...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594042/ https://www.ncbi.nlm.nih.gov/pubmed/23190879 http://dx.doi.org/10.1038/jid.2012.410 |
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author | Doctrow, Susan R. Lopez, Argelia Schock, Ashley M. Duncan, Nathan E. Jourdan, Megan M. Olasz, Edit B. Moulder, John E. Fish, Brian L. Mäder, Marylou Lazar, Jozef Lazarova, Zelmira |
author_facet | Doctrow, Susan R. Lopez, Argelia Schock, Ashley M. Duncan, Nathan E. Jourdan, Megan M. Olasz, Edit B. Moulder, John E. Fish, Brian L. Mäder, Marylou Lazar, Jozef Lazarova, Zelmira |
author_sort | Doctrow, Susan R. |
collection | PubMed |
description | In the event of a radionuclear attack or nuclear accident, the skin would be the first barrier exposed to radiation, though skin injury can progress over days to years following exposure. Chronic oxidative stress has been implicated as being a potential contributor to the progression of delayed radiation-induced injury to skin and other organs. To examine the causative role of oxidative stress in delayed radiation-induced skin injury, including impaired wound healing, we tested a synthetic superoxide dismutase (SOD)/catalase mimetic, EUK-207, in a rat model of combined skin irradiation and wound injury. Administered systemically, beginning 48 h after irradiation, EUK-207 mitigated radiation dermatitis, suppressed indicators of tissue oxidative stress, and enhanced wound healing. Evaluation of gene expression in irradiated skin at 30 days after exposure revealed a significant upregulation of several key genes involved in detoxication of reactive oxygen and nitrogen species. This gene expression pattern was primarily reversed by EUK-207 therapy. These results demonstrate that oxidative stress plays a critical role in the progression of radiation-induced skin injury, and that the injury can be mitigated by appropriate antioxidant compounds administered 48 h after exposure. |
format | Online Article Text |
id | pubmed-3594042 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
record_format | MEDLINE/PubMed |
spelling | pubmed-35940422013-10-01 A synthetic superoxide dismutase/catalase mimetic EUK-207 mitigates radiation dermatitis and promotes wound healing in irradiated rat skin Doctrow, Susan R. Lopez, Argelia Schock, Ashley M. Duncan, Nathan E. Jourdan, Megan M. Olasz, Edit B. Moulder, John E. Fish, Brian L. Mäder, Marylou Lazar, Jozef Lazarova, Zelmira J Invest Dermatol Article In the event of a radionuclear attack or nuclear accident, the skin would be the first barrier exposed to radiation, though skin injury can progress over days to years following exposure. Chronic oxidative stress has been implicated as being a potential contributor to the progression of delayed radiation-induced injury to skin and other organs. To examine the causative role of oxidative stress in delayed radiation-induced skin injury, including impaired wound healing, we tested a synthetic superoxide dismutase (SOD)/catalase mimetic, EUK-207, in a rat model of combined skin irradiation and wound injury. Administered systemically, beginning 48 h after irradiation, EUK-207 mitigated radiation dermatitis, suppressed indicators of tissue oxidative stress, and enhanced wound healing. Evaluation of gene expression in irradiated skin at 30 days after exposure revealed a significant upregulation of several key genes involved in detoxication of reactive oxygen and nitrogen species. This gene expression pattern was primarily reversed by EUK-207 therapy. These results demonstrate that oxidative stress plays a critical role in the progression of radiation-induced skin injury, and that the injury can be mitigated by appropriate antioxidant compounds administered 48 h after exposure. 2012-11-29 2013-04 /pmc/articles/PMC3594042/ /pubmed/23190879 http://dx.doi.org/10.1038/jid.2012.410 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Doctrow, Susan R. Lopez, Argelia Schock, Ashley M. Duncan, Nathan E. Jourdan, Megan M. Olasz, Edit B. Moulder, John E. Fish, Brian L. Mäder, Marylou Lazar, Jozef Lazarova, Zelmira A synthetic superoxide dismutase/catalase mimetic EUK-207 mitigates radiation dermatitis and promotes wound healing in irradiated rat skin |
title | A synthetic superoxide dismutase/catalase mimetic EUK-207 mitigates radiation dermatitis and promotes wound healing in irradiated rat skin |
title_full | A synthetic superoxide dismutase/catalase mimetic EUK-207 mitigates radiation dermatitis and promotes wound healing in irradiated rat skin |
title_fullStr | A synthetic superoxide dismutase/catalase mimetic EUK-207 mitigates radiation dermatitis and promotes wound healing in irradiated rat skin |
title_full_unstemmed | A synthetic superoxide dismutase/catalase mimetic EUK-207 mitigates radiation dermatitis and promotes wound healing in irradiated rat skin |
title_short | A synthetic superoxide dismutase/catalase mimetic EUK-207 mitigates radiation dermatitis and promotes wound healing in irradiated rat skin |
title_sort | synthetic superoxide dismutase/catalase mimetic euk-207 mitigates radiation dermatitis and promotes wound healing in irradiated rat skin |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594042/ https://www.ncbi.nlm.nih.gov/pubmed/23190879 http://dx.doi.org/10.1038/jid.2012.410 |
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