A Triad of Highly Divergent Polymeric Immunoglobulin Receptor (PIGR) Haplotypes with Major Effect on IgA Concentration in Bovine Milk

The aim of this study was to determine a genetic basis for IgA concentration in milk of Bos taurus. We used a Holstein-Friesian x Jersey F2 crossbred pedigree to undertake a genome-wide search for QTL influencing IgA concentration and yield in colostrum and milk. We identified a single genome-wide s...

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Autores principales: Berry, Sarah, Coppieters, Wouter, Davis, Stephen, Burrett, Alayna, Thomas, Natalie, Palmer, David, Kelly, Van, Obolonkin, Vladimir, Sanders, Kathryn, Spelman, Richard, Georges, Michel, Lehnert, Klaus, Snell, Russell
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
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Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594236/
https://www.ncbi.nlm.nih.gov/pubmed/23536764
http://dx.doi.org/10.1371/journal.pone.0057219
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author Berry, Sarah
Coppieters, Wouter
Davis, Stephen
Burrett, Alayna
Thomas, Natalie
Palmer, David
Kelly, Van
Obolonkin, Vladimir
Sanders, Kathryn
Spelman, Richard
Georges, Michel
Lehnert, Klaus
Snell, Russell
author_facet Berry, Sarah
Coppieters, Wouter
Davis, Stephen
Burrett, Alayna
Thomas, Natalie
Palmer, David
Kelly, Van
Obolonkin, Vladimir
Sanders, Kathryn
Spelman, Richard
Georges, Michel
Lehnert, Klaus
Snell, Russell
author_sort Berry, Sarah
collection PubMed
description The aim of this study was to determine a genetic basis for IgA concentration in milk of Bos taurus. We used a Holstein-Friesian x Jersey F2 crossbred pedigree to undertake a genome-wide search for QTL influencing IgA concentration and yield in colostrum and milk. We identified a single genome-wide significant QTL on chromosome 16, maximising at 4.8 Mbp. The polymeric immunoglobulin receptor gene (PIGR) was within the confidence interval of the QTL. In addition, mRNA expression analysis revealed a liver PIGR expression QTL mapping to the same locus as the IgA quantitative trait locus. Sequencing and subsequent genotyping of the PIGR gene revealed three divergent haplotypes that explained the variance of both the IgA QTL and the PIGR expression QTL. Genetic selection based on these markers will facilitate the production of bovine herds producing milk with higher concentrations of IgA.
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spelling pubmed-35942362013-03-27 A Triad of Highly Divergent Polymeric Immunoglobulin Receptor (PIGR) Haplotypes with Major Effect on IgA Concentration in Bovine Milk Berry, Sarah Coppieters, Wouter Davis, Stephen Burrett, Alayna Thomas, Natalie Palmer, David Kelly, Van Obolonkin, Vladimir Sanders, Kathryn Spelman, Richard Georges, Michel Lehnert, Klaus Snell, Russell PLoS One Research Article The aim of this study was to determine a genetic basis for IgA concentration in milk of Bos taurus. We used a Holstein-Friesian x Jersey F2 crossbred pedigree to undertake a genome-wide search for QTL influencing IgA concentration and yield in colostrum and milk. We identified a single genome-wide significant QTL on chromosome 16, maximising at 4.8 Mbp. The polymeric immunoglobulin receptor gene (PIGR) was within the confidence interval of the QTL. In addition, mRNA expression analysis revealed a liver PIGR expression QTL mapping to the same locus as the IgA quantitative trait locus. Sequencing and subsequent genotyping of the PIGR gene revealed three divergent haplotypes that explained the variance of both the IgA QTL and the PIGR expression QTL. Genetic selection based on these markers will facilitate the production of bovine herds producing milk with higher concentrations of IgA. Public Library of Science 2013-03-11 /pmc/articles/PMC3594236/ /pubmed/23536764 http://dx.doi.org/10.1371/journal.pone.0057219 Text en © 2013 Berry et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Berry, Sarah
Coppieters, Wouter
Davis, Stephen
Burrett, Alayna
Thomas, Natalie
Palmer, David
Kelly, Van
Obolonkin, Vladimir
Sanders, Kathryn
Spelman, Richard
Georges, Michel
Lehnert, Klaus
Snell, Russell
A Triad of Highly Divergent Polymeric Immunoglobulin Receptor (PIGR) Haplotypes with Major Effect on IgA Concentration in Bovine Milk
title A Triad of Highly Divergent Polymeric Immunoglobulin Receptor (PIGR) Haplotypes with Major Effect on IgA Concentration in Bovine Milk
title_full A Triad of Highly Divergent Polymeric Immunoglobulin Receptor (PIGR) Haplotypes with Major Effect on IgA Concentration in Bovine Milk
title_fullStr A Triad of Highly Divergent Polymeric Immunoglobulin Receptor (PIGR) Haplotypes with Major Effect on IgA Concentration in Bovine Milk
title_full_unstemmed A Triad of Highly Divergent Polymeric Immunoglobulin Receptor (PIGR) Haplotypes with Major Effect on IgA Concentration in Bovine Milk
title_short A Triad of Highly Divergent Polymeric Immunoglobulin Receptor (PIGR) Haplotypes with Major Effect on IgA Concentration in Bovine Milk
title_sort triad of highly divergent polymeric immunoglobulin receptor (pigr) haplotypes with major effect on iga concentration in bovine milk
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594236/
https://www.ncbi.nlm.nih.gov/pubmed/23536764
http://dx.doi.org/10.1371/journal.pone.0057219
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