The A-nucleotide preference of HIV-1 in the context of its structured RNA genome

A bipartition of HIV-1 RNA genome sequences into single- and double-stranded nucleotides is possible based on the secondary structure model of a complete 9 kb genome. Subsequent analysis revealed that the well-known lentiviral property of A-accumulation is profoundly present in single-stranded domai...

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Autores principales: van Hemert, Formijn J., van der Kuyl, Antoinette C., Berkhout, Ben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594280/
https://www.ncbi.nlm.nih.gov/pubmed/23235488
http://dx.doi.org/10.4161/rna.22896
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author van Hemert, Formijn J.
van der Kuyl, Antoinette C.
Berkhout, Ben
author_facet van Hemert, Formijn J.
van der Kuyl, Antoinette C.
Berkhout, Ben
author_sort van Hemert, Formijn J.
collection PubMed
description A bipartition of HIV-1 RNA genome sequences into single- and double-stranded nucleotides is possible based on the secondary structure model of a complete 9 kb genome. Subsequent analysis revealed that the well-known lentiviral property of A-accumulation is profoundly present in single-stranded domains, yet absent in double-stranded domains. Mutational rate analysis by means of an unrestricted model of nucleotide substitution suggests the presence of an evolutionary equilibrium to preserve this biased nucleotide distribution.
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spelling pubmed-35942802013-03-22 The A-nucleotide preference of HIV-1 in the context of its structured RNA genome van Hemert, Formijn J. van der Kuyl, Antoinette C. Berkhout, Ben RNA Biol Research Paper A bipartition of HIV-1 RNA genome sequences into single- and double-stranded nucleotides is possible based on the secondary structure model of a complete 9 kb genome. Subsequent analysis revealed that the well-known lentiviral property of A-accumulation is profoundly present in single-stranded domains, yet absent in double-stranded domains. Mutational rate analysis by means of an unrestricted model of nucleotide substitution suggests the presence of an evolutionary equilibrium to preserve this biased nucleotide distribution. Landes Bioscience 2013-02-01 /pmc/articles/PMC3594280/ /pubmed/23235488 http://dx.doi.org/10.4161/rna.22896 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Research Paper
van Hemert, Formijn J.
van der Kuyl, Antoinette C.
Berkhout, Ben
The A-nucleotide preference of HIV-1 in the context of its structured RNA genome
title The A-nucleotide preference of HIV-1 in the context of its structured RNA genome
title_full The A-nucleotide preference of HIV-1 in the context of its structured RNA genome
title_fullStr The A-nucleotide preference of HIV-1 in the context of its structured RNA genome
title_full_unstemmed The A-nucleotide preference of HIV-1 in the context of its structured RNA genome
title_short The A-nucleotide preference of HIV-1 in the context of its structured RNA genome
title_sort a-nucleotide preference of hiv-1 in the context of its structured rna genome
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594280/
https://www.ncbi.nlm.nih.gov/pubmed/23235488
http://dx.doi.org/10.4161/rna.22896
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