Inactivation of DNA–Dependent Protein Kinase Promotes Heat–Induced Apoptosis Independently of Heat–Shock Protein Induction in Human Cancer Cell Lines

The inhibition of DNA damage response pathway seems to be an attractive strategy for cancer therapy. It was previously reported that in rodent cells exposed to heat stress, cell growth was promoted by the activity of DNA-dependent protein kinase (DNA-PK), an enzyme involved in DNA non-homologous end...

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Detalles Bibliográficos
Autores principales: Okazawa, Seisuke, Furusawa, Yukihiro, Kariya, Ayako, Hassan, Mariame Ali, Arai, Mie, Hayashi, Ryuji, Tabuchi, Yoshiaki, Kondo, Takashi, Tobe, Kazuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594312/
https://www.ncbi.nlm.nih.gov/pubmed/23505488
http://dx.doi.org/10.1371/journal.pone.0058325

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