Altered Expression of MGMT in High-Grade Gliomas Results from the Combined Effect of Epigenetic and Genetic Aberrations

MGMT downregulation in high-grade gliomas (HGG) has been mostly attributed to aberrant promoter methylation and is associated with increased sensitivity to alkylating agent-based chemotherapy. However, HGG harboring 10q deletions also benefit from treatment with alkylating agents. Because the MGMT g...

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Detalles Bibliográficos
Autores principales: Ramalho-Carvalho, João, Pires, Malini, Lisboa, Susana, Graça, Inês, Rocha, Patrícia, Barros-Silva, João Diogo, Savva-Bordalo, Joana, Maurício, Joaquina, Resende, Mário, Teixeira, Manuel R., Honavar, Mrinalini, Henrique, Rui, Jerónimo, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594314/
https://www.ncbi.nlm.nih.gov/pubmed/23505468
http://dx.doi.org/10.1371/journal.pone.0058206

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