Decreased cortical muscarinic M1 receptors in schizophrenia are associated with changes in gene promoter methylation, mRNA and gene targeting microRNA

Many studies have shown decreased cortical muscarinic M1 receptors (CHRM1) in schizophrenia (Sz), with one study showing Sz can be separated into two populations based on a marked loss of CHRM1 (∼75%) in ∼25% of people (Def-Sz) with the disorder. To better understand the mechanism contributing to th...

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Detalles Bibliográficos
Autores principales: Scarr, E, Craig, J M, Cairns, M J, Seo, M S, Galati, J C, Beveridge, N J, Gibbons, A, Juzva, S, Weinrich, B, Parkinson-Bates, M, Carroll, A P, Saffery, R, Dean, B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594731/
https://www.ncbi.nlm.nih.gov/pubmed/23423139
http://dx.doi.org/10.1038/tp.2013.3

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