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A Novel Synthetic Microtubule Inhibitor, MPT0B214 Exhibits Antitumor Activity in Human Tumor Cells through Mitochondria-Dependent Intrinsic Pathway

Agents that interfere with mitotic progression by disturbing microtubule dynamics are commonly used for cancer treatment. Previously, a series of aroylquinolone regioisomers as novel microtubule inhibitors were discovered. One of these new compounds, MPT0B214 inhibited tubulin polymerization through...

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Detalles Bibliográficos
Autores principales:	Chiang, Nai-Jung, Lin, Ching-I, Liou, Jing-Ping, Kuo, Ching-Chuan, Chang, Chi-Yen, Chen, Li-Tzong, Chang, Jang-Yang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595215/ https://www.ncbi.nlm.nih.gov/pubmed/23554962 http://dx.doi.org/10.1371/journal.pone.0058953

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