Cargando…
Interleukin-27 Signaling Promotes Immunity against Endogenously Arising Murine Tumors
Interleukin-27 (IL-27) is a pleiotropic cytokine but its immunosuppressive effects predominate during many in vivo immunological challenges. Despite this, evidence from tumor cell line transfer models suggested that IL-27 could promote immune responses in the tumor context. However, the role of IL-2...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595259/ https://www.ncbi.nlm.nih.gov/pubmed/23554861 http://dx.doi.org/10.1371/journal.pone.0057469 |
_version_ | 1782262401943470080 |
---|---|
author | Natividad, Karlo D. T. Junankar, Simon R. Mohd Redzwan, Norhanani Nair, Radhika Wirasinha, Rushika C. King, Cecile Brink, Robert Swarbrick, Alexander Batten, Marcel |
author_facet | Natividad, Karlo D. T. Junankar, Simon R. Mohd Redzwan, Norhanani Nair, Radhika Wirasinha, Rushika C. King, Cecile Brink, Robert Swarbrick, Alexander Batten, Marcel |
author_sort | Natividad, Karlo D. T. |
collection | PubMed |
description | Interleukin-27 (IL-27) is a pleiotropic cytokine but its immunosuppressive effects predominate during many in vivo immunological challenges. Despite this, evidence from tumor cell line transfer models suggested that IL-27 could promote immune responses in the tumor context. However, the role of IL-27 in immunity against tumors that develop in situ and in tumor immunosurveillance remain undefined. In this study, we demonstrate that tumor development and growth are accelerated in IL-27 receptor α (Il27ra)-deficient mice. Enhanced tumor growth in both carcinogen-induced fibrosarcoma and oncogene-driven mammary carcinoma was associated with decreased interferon-γ production by CD4 and CD8 T cells and increased numbers of regulatory T-cells (T(reg)). This is the first study to show that IL-27 promotes protective immune responses against endogenous tumors, which is critical as the basis for future development of an IL-27 based therapeutic agent. |
format | Online Article Text |
id | pubmed-3595259 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-35952592013-04-02 Interleukin-27 Signaling Promotes Immunity against Endogenously Arising Murine Tumors Natividad, Karlo D. T. Junankar, Simon R. Mohd Redzwan, Norhanani Nair, Radhika Wirasinha, Rushika C. King, Cecile Brink, Robert Swarbrick, Alexander Batten, Marcel PLoS One Research Article Interleukin-27 (IL-27) is a pleiotropic cytokine but its immunosuppressive effects predominate during many in vivo immunological challenges. Despite this, evidence from tumor cell line transfer models suggested that IL-27 could promote immune responses in the tumor context. However, the role of IL-27 in immunity against tumors that develop in situ and in tumor immunosurveillance remain undefined. In this study, we demonstrate that tumor development and growth are accelerated in IL-27 receptor α (Il27ra)-deficient mice. Enhanced tumor growth in both carcinogen-induced fibrosarcoma and oncogene-driven mammary carcinoma was associated with decreased interferon-γ production by CD4 and CD8 T cells and increased numbers of regulatory T-cells (T(reg)). This is the first study to show that IL-27 promotes protective immune responses against endogenous tumors, which is critical as the basis for future development of an IL-27 based therapeutic agent. Public Library of Science 2013-03-12 /pmc/articles/PMC3595259/ /pubmed/23554861 http://dx.doi.org/10.1371/journal.pone.0057469 Text en © 2013 Natividad et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Natividad, Karlo D. T. Junankar, Simon R. Mohd Redzwan, Norhanani Nair, Radhika Wirasinha, Rushika C. King, Cecile Brink, Robert Swarbrick, Alexander Batten, Marcel Interleukin-27 Signaling Promotes Immunity against Endogenously Arising Murine Tumors |
title | Interleukin-27 Signaling Promotes Immunity against Endogenously Arising Murine Tumors |
title_full | Interleukin-27 Signaling Promotes Immunity against Endogenously Arising Murine Tumors |
title_fullStr | Interleukin-27 Signaling Promotes Immunity against Endogenously Arising Murine Tumors |
title_full_unstemmed | Interleukin-27 Signaling Promotes Immunity against Endogenously Arising Murine Tumors |
title_short | Interleukin-27 Signaling Promotes Immunity against Endogenously Arising Murine Tumors |
title_sort | interleukin-27 signaling promotes immunity against endogenously arising murine tumors |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595259/ https://www.ncbi.nlm.nih.gov/pubmed/23554861 http://dx.doi.org/10.1371/journal.pone.0057469 |
work_keys_str_mv | AT natividadkarlodt interleukin27signalingpromotesimmunityagainstendogenouslyarisingmurinetumors AT junankarsimonr interleukin27signalingpromotesimmunityagainstendogenouslyarisingmurinetumors AT mohdredzwannorhanani interleukin27signalingpromotesimmunityagainstendogenouslyarisingmurinetumors AT nairradhika interleukin27signalingpromotesimmunityagainstendogenouslyarisingmurinetumors AT wirasinharushikac interleukin27signalingpromotesimmunityagainstendogenouslyarisingmurinetumors AT kingcecile interleukin27signalingpromotesimmunityagainstendogenouslyarisingmurinetumors AT brinkrobert interleukin27signalingpromotesimmunityagainstendogenouslyarisingmurinetumors AT swarbrickalexander interleukin27signalingpromotesimmunityagainstendogenouslyarisingmurinetumors AT battenmarcel interleukin27signalingpromotesimmunityagainstendogenouslyarisingmurinetumors |