Cargando…

The Akt Inhibitor ISC-4 Synergizes with Cetuximab in 5-FU-Resistant Colon Cancer

Phenylbutyl isoselenocyanate (ISC-4) is an Akt inhibitor with demonstrated preclinical efficacy against melanoma and colon cancer. In this study, we sought to improve the clinical utility of ISC-4 by identifying a synergistic combination with FDA-approved anti-cancer therapies, a relevant and approp...

Descripción completa

Detalles Bibliográficos
Autores principales:	Allen, Joshua E., Gallant, Jean-Nicolas, Dicker, David T., Amin, Shantu, Irby, Rosalyn B., Sharma, Arun K., El-Deiry, Wafik S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595267/ https://www.ncbi.nlm.nih.gov/pubmed/23555026 http://dx.doi.org/10.1371/journal.pone.0059380

Ejemplares similares

Correction: The Akt Inhibitor ISC-4 Synergizes with Cetuximab in 5-FU-Resistant Colon Cancer
por: Allen, Joshua E., et al.
Publicado: (2013)

Calcein-effluxing human colon cancer cells are enriched for self-renewal capacity and depend on β-catenin
por: Allen, Joshua E., et al.
Publicado: (2013)

The PI3K/AKT Pathway Inhibitor ISC-4 Induces Apoptosis and Inhibits Growth of Leukemia in Preclinical Models of Acute Myeloid Leukemia
por: Annageldiyev, Charyguly, et al.
Publicado: (2020)

Prostate apoptosis response protein 4 sensitizes human colon cancer cells to chemotherapeutic 5-FU through mediation of an NFκB and microRNA network
por: Wang, Bi-Dar, et al.
Publicado: (2010)

Detection of circulating tumor cells in the cerebrospinal fluid of a patient with a solitary metastasis from breast cancer: A case report
por: PATEL, AKSHAL S., et al.
Publicado: (2014)

Regulation of the human TRAIL gene
por: Allen, Joshua E., et al.
Publicado: (2012)

Targeting Oncoproteins for Molecular Cancer Therapy
por: Allen, Joshua E., et al.
Publicado: (2016)

Personalizing Colon Cancer Therapeutics: Targeting Old and New Mechanisms of Action
por: Kline, Christina Leah B., et al.
Publicado: (2013)

Identification of TRAIL-inducing compounds highlights small molecule ONC201/TIC10 as a unique anti-cancer agent that activates the TRAIL pathway
por: Allen, Joshua E, et al.
Publicado: (2015)

Request for additional beam time for 1994 for ISC/P42 and ISC/P48, (ISC 330 and ISC 331): use of radioactive ion beams for biomedical research
por: Beyer, Gerd-Jürgen, et al.
Publicado: (1994)

Identification and enumeration of circulating tumor cells in the cerebrospinal fluid of breast cancer patients with central nervous system metastases
por: Patel, Akshal S., et al.
Publicado: (2011)

First-In-Class Small Molecule ONC201 Induces DR5 and Cell Death in Tumor but Not Normal Cells to Provide a Wide Therapeutic Index as an Anti-Cancer Agent
por: Allen, Joshua E., et al.
Publicado: (2015)

TRIM21 is a novel regulator of Par-4 in colon and pancreatic cancer cells
por: Nguyen, Jeffrey Q., et al.
Publicado: (2016)

Pan-drug and drug-specific mechanisms of 5-FU, irinotecan (CPT-11), oxaliplatin, and cisplatin identified by comparison of transcriptomic and cytokine responses of colorectal cancer cells
por: Carlsen, Lindsey, et al.
Publicado: (2021)

Sorafenib Sensitizes Solid Tumors to Apo2L/TRAIL and Apo2L/TRAIL Receptor Agonist Antibodies by the Jak2-Stat3-Mcl1 Axis
por: Abdulghani, Junaid, et al.
Publicado: (2013)

Exosomes promote cetuximab resistance via the PTEN/Akt pathway in colon cancer cells
por: Zhang, S., et al.
Publicado: (2017)

Correction: First-In-Class Small Molecule ONC201 Induces DR5 and Cell Death in Tumor but Not Normal Cells to Provide a Wide Therapeutic Index as an Anti-Cancer Agent
por: Allen, Joshua E., et al.
Publicado: (2016)

Novel Seleno-Aspirinyl Compound AS-10 Induces Apoptosis, G1 Arrest of Pancreatic Ductal Adenocarcinoma Cells, Inhibits Their NF-κB Signaling, and Synergizes with Gemcitabine Cytotoxicity
por: Karelia, Deepkamal N., et al.
Publicado: (2021)

Circulating tumor cells: silent predictors of metastasis
por: Zhou, LanLan, et al.
Publicado: (2017)

The angular structure of ONC201, a TRAIL pathway-inducing compound, determines its potent anti-cancer activity
por: Wagner, Jessica, et al.
Publicado: (2015)

Apoptotic circulating tumor cells (CTCs) in the peripheral blood of metastatic colorectal cancer patients are associated with liver metastasis but not CTCs
por: Allen, Joshua E., et al.
Publicado: (2013)

Official (ISC)² guide to the CSSLP
por: Paul, Mano
Publicado: (2011)

Backlog review of the ISC experiments
por: Eades, John
Publicado: (2000)

A high-throughput customized cytokinome screen of colon cancer cell responses to small-molecule oncology drugs
por: Huntington, Kelsey E., et al.
Publicado: (2021)

Anti-cancer efficacy including Rb-deficient tumors and VHL-independent HIF1α proteasomal destabilization by dual targeting of CDK1 or CDK4/6 and HSP90
por: Zhao, Shuai, et al.
Publicado: (2021)

IS303: an update on the proposals ISC 91-11/P8 and ISC 96-31/P87
por: Hass, Michael
Publicado: (2000)

A New Tessera into the Interactome of the isc Operon: A Novel Interaction between HscB and IscS
por: Puglisi, Rita, et al.
Publicado: (2016)

Investing in biomedical research is important
por: El-Deiry, Wafik S
Publicado: (2013)

Welcoming Paul Dent as Assistant Editor-in-Chief of Cancer Biology & Therapy
por: El-Deiry, Wafik S
Publicado: (2013)

Are we losing the war on cancer?
por: El-Deiry, Wafik S
Publicado: (2013)

Targeting Mutated p53: Naivete and Enthusiasm to Attempt the Impossible
por: El-Deiry, Wafik S.
Publicado: (2023)

Role of Dopamine Receptors in the Anticancer Activity of ONC201()()
por: Kline, Christina Leah B., et al.
Publicado: (2017)

Mechanism of acquired 5FU resistance and strategy for overcoming 5FU resistance focusing on 5FU metabolism in colon cancer cell lines
por: Suetsugu, Tomonari, et al.
Publicado: (2021)

Official (ISC)² guide to the CAP CBK
por: Howard, Patrick D
Publicado: (2013)

CISSP official (ISC)² practice tests
por: Seidl, David, et al.
Publicado: (2016)

Multiple Sulfur Acceptors Dock at IscS
por: Heller, Kira
Publicado: (2010)

ISC members and ex-officio members
por: CERN. Geneva. ISOLDE Experiments Committee
Publicado: (1992)

Minutes, CERN-ISC-97-22
por: CERN. Geneva. ISOLDE Experiments Committee
Publicado: (1997)

P53-independent partial restoration of the p53 pathway in tumors with mutated p53 through ATF4 transcriptional modulation by ERK1/2 and CDK9
por: Tian, Xiaobing, et al.
Publicado: (2021)

The iron-sulfur cluster assembly genes iscS and iscU of Entamoeba histolytica were acquired by horizontal gene transfer
por: van der Giezen, Mark, et al.
Publicado: (2004)

Cannot write session to /tmp/vufind_sessions/sess_brv8n3psu1th9dajd5uh6un88b