Consideration of Rat Chronic Progressive Nephropathy in Regulatory Evaluations for Carcinogenicity

Chronic progressive nephropathy (CPN) is a spontaneous renal disease of rats which can be a serious confounder in toxicology studies. It is a progressive disease with known physiological factors that modify disease progression, such as high dietary protein. The weight of evidence supports an absence...

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Detalles Bibliográficos
Autores principales: Hard, Gordon C., Banton, Marcy I., Bretzlaff, Robert S., Dekant, Wolfgang, Fowles, Jefferson R., Mallett, Anthony K., McGregor, Douglas B., Roberts, Kathleen M., Sielken, Robert L., Valdez-Flores, Ciriaco, Cohen, Samuel M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Forum
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595520/
https://www.ncbi.nlm.nih.gov/pubmed/23104430
http://dx.doi.org/10.1093/toxsci/kfs305

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