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Harnessing DNA Synthesis to Develop Rapid Responses to Emerging and Pandemic Pathogens
Given the interconnected nature of our world today, emerging pathogens and pandemic outbreaks are an ever-growing threat to the health and economic stability of the global community. This is evident by the recent 2009 Influenza A (H1N1) pandemic, the SARS outbreak, as well as the ever-present threat...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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SAGE-Hindawi Access to Research
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595711/ https://www.ncbi.nlm.nih.gov/pubmed/23533775 http://dx.doi.org/10.4061/2011/765763 |
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author | Runco, Lisa M. Coleman, J. Robert |
author_facet | Runco, Lisa M. Coleman, J. Robert |
author_sort | Runco, Lisa M. |
collection | PubMed |
description | Given the interconnected nature of our world today, emerging pathogens and pandemic outbreaks are an ever-growing threat to the health and economic stability of the global community. This is evident by the recent 2009 Influenza A (H1N1) pandemic, the SARS outbreak, as well as the ever-present threat of global bioterrorism. Fortunately, the biomedical community has been able to rapidly generate sequence data so these pathogens can be readily identified. To date, however, the utilization of this sequence data to rapidly produce relevant experimental results or actionable treatments is lagging in spite of obtained sequence data. Thus, a pathogenic threat that has emerged and/or developed into a pandemic can be rapidly identified; however, translating this identification into a targeted therapeutic or treatment that is rapidly available has not yet materialized. This commentary suggests that the growing technology of DNA synthesis should be fully implemented as a means to rapidly generate in vivo data and possibly actionable therapeutics soon after sequence data becomes available. |
format | Online Article Text |
id | pubmed-3595711 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | SAGE-Hindawi Access to Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-35957112013-03-26 Harnessing DNA Synthesis to Develop Rapid Responses to Emerging and Pandemic Pathogens Runco, Lisa M. Coleman, J. Robert J Pathog Review Article Given the interconnected nature of our world today, emerging pathogens and pandemic outbreaks are an ever-growing threat to the health and economic stability of the global community. This is evident by the recent 2009 Influenza A (H1N1) pandemic, the SARS outbreak, as well as the ever-present threat of global bioterrorism. Fortunately, the biomedical community has been able to rapidly generate sequence data so these pathogens can be readily identified. To date, however, the utilization of this sequence data to rapidly produce relevant experimental results or actionable treatments is lagging in spite of obtained sequence data. Thus, a pathogenic threat that has emerged and/or developed into a pandemic can be rapidly identified; however, translating this identification into a targeted therapeutic or treatment that is rapidly available has not yet materialized. This commentary suggests that the growing technology of DNA synthesis should be fully implemented as a means to rapidly generate in vivo data and possibly actionable therapeutics soon after sequence data becomes available. SAGE-Hindawi Access to Research 2011 2011-03-16 /pmc/articles/PMC3595711/ /pubmed/23533775 http://dx.doi.org/10.4061/2011/765763 Text en Copyright © 2011 L. M. Runco and J. R. Coleman. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Runco, Lisa M. Coleman, J. Robert Harnessing DNA Synthesis to Develop Rapid Responses to Emerging and Pandemic Pathogens |
title | Harnessing DNA Synthesis to Develop Rapid Responses to Emerging and Pandemic Pathogens |
title_full | Harnessing DNA Synthesis to Develop Rapid Responses to Emerging and Pandemic Pathogens |
title_fullStr | Harnessing DNA Synthesis to Develop Rapid Responses to Emerging and Pandemic Pathogens |
title_full_unstemmed | Harnessing DNA Synthesis to Develop Rapid Responses to Emerging and Pandemic Pathogens |
title_short | Harnessing DNA Synthesis to Develop Rapid Responses to Emerging and Pandemic Pathogens |
title_sort | harnessing dna synthesis to develop rapid responses to emerging and pandemic pathogens |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595711/ https://www.ncbi.nlm.nih.gov/pubmed/23533775 http://dx.doi.org/10.4061/2011/765763 |
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