Successful Treatment of Recurrent Primary Sclerosing Cholangitis after Orthotopic Liver Transplantation with Oral Vancomycin

Primary sclerosing cholangitis (PSC) is a progressive, cholestatic disease of the liver that is marked by inflammation of the bile ducts and damage to the hepatic biliary tree. Approximately 60–70% of patients also have inflammatory bowel disease and progression of PSC can lead to ulcerative colitis...

Descripción completa

Detalles Bibliográficos
Autores principales: Davies, Yinka K., Tsay, Cynthia J., Caccamo, Dario V., Cox, Kathleen M., Castillo, Ricardo O., Cox, Kenneth L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595721/
https://www.ncbi.nlm.nih.gov/pubmed/23509657
http://dx.doi.org/10.1155/2013/314292
_version_ 1782262449707155456
author Davies, Yinka K.
Tsay, Cynthia J.
Caccamo, Dario V.
Cox, Kathleen M.
Castillo, Ricardo O.
Cox, Kenneth L.
author_facet Davies, Yinka K.
Tsay, Cynthia J.
Caccamo, Dario V.
Cox, Kathleen M.
Castillo, Ricardo O.
Cox, Kenneth L.
author_sort Davies, Yinka K.
collection PubMed
description Primary sclerosing cholangitis (PSC) is a progressive, cholestatic disease of the liver that is marked by inflammation of the bile ducts and damage to the hepatic biliary tree. Approximately 60–70% of patients also have inflammatory bowel disease and progression of PSC can lead to ulcerative colitis and cirrhosis of the liver. Due to limited understanding of the etiology and mechanism of PSC, the only existing treatment option is orthotopic liver transplantation (OLT); however, recurrence of PSC, after OLT is estimated to be between 5% and 35%. We discuss the successful treatment of a pediatric patient, with recurrent PSC, after OLT with oral Vancomycin.
format Online
Article
Text
id pubmed-3595721
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-35957212013-03-18 Successful Treatment of Recurrent Primary Sclerosing Cholangitis after Orthotopic Liver Transplantation with Oral Vancomycin Davies, Yinka K. Tsay, Cynthia J. Caccamo, Dario V. Cox, Kathleen M. Castillo, Ricardo O. Cox, Kenneth L. Case Rep Transplant Case Report Primary sclerosing cholangitis (PSC) is a progressive, cholestatic disease of the liver that is marked by inflammation of the bile ducts and damage to the hepatic biliary tree. Approximately 60–70% of patients also have inflammatory bowel disease and progression of PSC can lead to ulcerative colitis and cirrhosis of the liver. Due to limited understanding of the etiology and mechanism of PSC, the only existing treatment option is orthotopic liver transplantation (OLT); however, recurrence of PSC, after OLT is estimated to be between 5% and 35%. We discuss the successful treatment of a pediatric patient, with recurrent PSC, after OLT with oral Vancomycin. Hindawi Publishing Corporation 2013 2013-02-24 /pmc/articles/PMC3595721/ /pubmed/23509657 http://dx.doi.org/10.1155/2013/314292 Text en Copyright © 2013 Yinka K. Davies et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Davies, Yinka K.
Tsay, Cynthia J.
Caccamo, Dario V.
Cox, Kathleen M.
Castillo, Ricardo O.
Cox, Kenneth L.
Successful Treatment of Recurrent Primary Sclerosing Cholangitis after Orthotopic Liver Transplantation with Oral Vancomycin
title Successful Treatment of Recurrent Primary Sclerosing Cholangitis after Orthotopic Liver Transplantation with Oral Vancomycin
title_full Successful Treatment of Recurrent Primary Sclerosing Cholangitis after Orthotopic Liver Transplantation with Oral Vancomycin
title_fullStr Successful Treatment of Recurrent Primary Sclerosing Cholangitis after Orthotopic Liver Transplantation with Oral Vancomycin
title_full_unstemmed Successful Treatment of Recurrent Primary Sclerosing Cholangitis after Orthotopic Liver Transplantation with Oral Vancomycin
title_short Successful Treatment of Recurrent Primary Sclerosing Cholangitis after Orthotopic Liver Transplantation with Oral Vancomycin
title_sort successful treatment of recurrent primary sclerosing cholangitis after orthotopic liver transplantation with oral vancomycin
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595721/
https://www.ncbi.nlm.nih.gov/pubmed/23509657
http://dx.doi.org/10.1155/2013/314292
work_keys_str_mv AT daviesyinkak successfultreatmentofrecurrentprimarysclerosingcholangitisafterorthotopiclivertransplantationwithoralvancomycin
AT tsaycynthiaj successfultreatmentofrecurrentprimarysclerosingcholangitisafterorthotopiclivertransplantationwithoralvancomycin
AT caccamodariov successfultreatmentofrecurrentprimarysclerosingcholangitisafterorthotopiclivertransplantationwithoralvancomycin
AT coxkathleenm successfultreatmentofrecurrentprimarysclerosingcholangitisafterorthotopiclivertransplantationwithoralvancomycin
AT castilloricardoo successfultreatmentofrecurrentprimarysclerosingcholangitisafterorthotopiclivertransplantationwithoralvancomycin
AT coxkennethl successfultreatmentofrecurrentprimarysclerosingcholangitisafterorthotopiclivertransplantationwithoralvancomycin

Ejemplares similares