Efficient synthesis of β’-amino-α,β-unsaturated ketones

A general and simple procedure to access chiral β'-amino-α,β-enones, in seven steps, from an α,β unsaturated ester has been described. The use of a Horner–Wadsworth–Emmons reaction as a key step for generating the β'-amino-α,β-enones, permits access to a range of substrates under mild cond...

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Detalles Bibliográficos
Autores principales: Abrunhosa-Thomas, Isabelle, Plas, Aurélie, Kandepedu, Nishanth, Chalard, Pierre, Troin, Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2013
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596044/
https://www.ncbi.nlm.nih.gov/pubmed/23504648
http://dx.doi.org/10.3762/bjoc.9.52
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author Abrunhosa-Thomas, Isabelle
Plas, Aurélie
Kandepedu, Nishanth
Chalard, Pierre
Troin, Yves
author_facet Abrunhosa-Thomas, Isabelle
Plas, Aurélie
Kandepedu, Nishanth
Chalard, Pierre
Troin, Yves
author_sort Abrunhosa-Thomas, Isabelle
collection PubMed
description A general and simple procedure to access chiral β'-amino-α,β-enones, in seven steps, from an α,β unsaturated ester has been described. The use of a Horner–Wadsworth–Emmons reaction as a key step for generating the β'-amino-α,β-enones, permits access to a range of substrates under mild conditions and in moderate to high yield.
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spelling pubmed-35960442013-03-15 Efficient synthesis of β’-amino-α,β-unsaturated ketones Abrunhosa-Thomas, Isabelle Plas, Aurélie Kandepedu, Nishanth Chalard, Pierre Troin, Yves Beilstein J Org Chem Letter A general and simple procedure to access chiral β'-amino-α,β-enones, in seven steps, from an α,β unsaturated ester has been described. The use of a Horner–Wadsworth–Emmons reaction as a key step for generating the β'-amino-α,β-enones, permits access to a range of substrates under mild conditions and in moderate to high yield. Beilstein-Institut 2013-03-06 /pmc/articles/PMC3596044/ /pubmed/23504648 http://dx.doi.org/10.3762/bjoc.9.52 Text en Copyright © 2013, Abrunhosa-Thomas et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Letter
Abrunhosa-Thomas, Isabelle
Plas, Aurélie
Kandepedu, Nishanth
Chalard, Pierre
Troin, Yves
Efficient synthesis of β’-amino-α,β-unsaturated ketones
title Efficient synthesis of β’-amino-α,β-unsaturated ketones
title_full Efficient synthesis of β’-amino-α,β-unsaturated ketones
title_fullStr Efficient synthesis of β’-amino-α,β-unsaturated ketones
title_full_unstemmed Efficient synthesis of β’-amino-α,β-unsaturated ketones
title_short Efficient synthesis of β’-amino-α,β-unsaturated ketones
title_sort efficient synthesis of β’-amino-α,β-unsaturated ketones
topic Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596044/
https://www.ncbi.nlm.nih.gov/pubmed/23504648
http://dx.doi.org/10.3762/bjoc.9.52
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