Towards a biocompatible artificial lung: Covalent functionalization of poly(4-methylpent-1-ene) (TPX) with cRGD pentapeptide

Covalent multistep coating of poly(methylpentene), the membrane material in lung ventilators, by using a copper-free “click” approach with a modified cyclic RGD peptide, leads to a highly biocompatible poly(methylpentene) surface. The resulting modified membrane preserves the required excellent gas-...

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Detalles Bibliográficos
Autores principales: Möller, Lena, Hess, Christian, Paleček, Jiří, Su, Yi, Haverich, Axel, Kirschning, Andreas, Dräger, Gerald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2013
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596089/
https://www.ncbi.nlm.nih.gov/pubmed/23504394
http://dx.doi.org/10.3762/bjoc.9.33
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author Möller, Lena
Hess, Christian
Paleček, Jiří
Su, Yi
Haverich, Axel
Kirschning, Andreas
Dräger, Gerald
author_facet Möller, Lena
Hess, Christian
Paleček, Jiří
Su, Yi
Haverich, Axel
Kirschning, Andreas
Dräger, Gerald
author_sort Möller, Lena
collection PubMed
description Covalent multistep coating of poly(methylpentene), the membrane material in lung ventilators, by using a copper-free “click” approach with a modified cyclic RGD peptide, leads to a highly biocompatible poly(methylpentene) surface. The resulting modified membrane preserves the required excellent gas-flow properties while being densely seeded with lung endothelial cells.
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spelling pubmed-35960892013-03-15 Towards a biocompatible artificial lung: Covalent functionalization of poly(4-methylpent-1-ene) (TPX) with cRGD pentapeptide Möller, Lena Hess, Christian Paleček, Jiří Su, Yi Haverich, Axel Kirschning, Andreas Dräger, Gerald Beilstein J Org Chem Full Research Paper Covalent multistep coating of poly(methylpentene), the membrane material in lung ventilators, by using a copper-free “click” approach with a modified cyclic RGD peptide, leads to a highly biocompatible poly(methylpentene) surface. The resulting modified membrane preserves the required excellent gas-flow properties while being densely seeded with lung endothelial cells. Beilstein-Institut 2013-02-08 /pmc/articles/PMC3596089/ /pubmed/23504394 http://dx.doi.org/10.3762/bjoc.9.33 Text en Copyright © 2013, Möller et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Möller, Lena
Hess, Christian
Paleček, Jiří
Su, Yi
Haverich, Axel
Kirschning, Andreas
Dräger, Gerald
Towards a biocompatible artificial lung: Covalent functionalization of poly(4-methylpent-1-ene) (TPX) with cRGD pentapeptide
title Towards a biocompatible artificial lung: Covalent functionalization of poly(4-methylpent-1-ene) (TPX) with cRGD pentapeptide
title_full Towards a biocompatible artificial lung: Covalent functionalization of poly(4-methylpent-1-ene) (TPX) with cRGD pentapeptide
title_fullStr Towards a biocompatible artificial lung: Covalent functionalization of poly(4-methylpent-1-ene) (TPX) with cRGD pentapeptide
title_full_unstemmed Towards a biocompatible artificial lung: Covalent functionalization of poly(4-methylpent-1-ene) (TPX) with cRGD pentapeptide
title_short Towards a biocompatible artificial lung: Covalent functionalization of poly(4-methylpent-1-ene) (TPX) with cRGD pentapeptide
title_sort towards a biocompatible artificial lung: covalent functionalization of poly(4-methylpent-1-ene) (tpx) with crgd pentapeptide
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596089/
https://www.ncbi.nlm.nih.gov/pubmed/23504394
http://dx.doi.org/10.3762/bjoc.9.33
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