COX19 mediates the transduction of a mitochondrial redox signal from SCO1 that regulates ATP7A-mediated cellular copper efflux

SCO1 and SCO2 are metallochaperones whose principal function is to add two copper ions to the catalytic core of cytochrome c oxidase (COX). However, affected tissues of SCO1 and SCO2 patients exhibit a combined deficiency in COX activity and total copper content, suggesting additional roles for thes...

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Detalles Bibliográficos
Autores principales: Leary, Scot C., Cobine, Paul A., Nishimura, Tamiko, Verdijk, Robert M., de Krijger, Ronald, de Coo, René, Tarnopolsky, Mark A., Winge, Dennis R., Shoubridge, Eric A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2013
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596241/
https://www.ncbi.nlm.nih.gov/pubmed/23345593
http://dx.doi.org/10.1091/mbc.E12-09-0705

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