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Phosphorylation on Ser-279 and Ser-282 of connexin43 regulates endocytosis and gap junction assembly in pancreatic cancer cells

The molecular mechanisms regulating the assembly of connexins (Cxs) into gap junctions are poorly understood. Using human pancreatic tumor cell lines BxPC3 and Capan-1, which express Cx26 and Cx43, we show that, upon arrival at the cell surface, the assembly of Cx43 is impaired. Connexin43 fails to...

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Detalles Bibliográficos
Autores principales:	Johnson, Kristen E., Mitra, Shalini, Katoch, Parul, Kelsey, Linda S., Johnson, Keith R., Mehta, Parmender P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2013
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596244/ https://www.ncbi.nlm.nih.gov/pubmed/23363606 http://dx.doi.org/10.1091/mbc.E12-07-0537

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