Gadd45g Is Essential for Primary Sex Determination, Male Fertility and Testis Development

In humans and most mammals, differentiation of the embryonic gonad into ovaries or testes is controlled by the Y-linked gene SRY. Here we show a role for the Gadd45g protein in this primary sex differentiation. We characterized mice deficient in Gadd45a, Gadd45b and Gadd45g, as well as double-knocko...

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Detalles Bibliográficos
Autores principales: Johnen, Heiko, González-Silva, Laura, Carramolino, Laura, Flores, Juana Maria, Torres, Miguel, Salvador, Jesús M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596291/
https://www.ncbi.nlm.nih.gov/pubmed/23516551
http://dx.doi.org/10.1371/journal.pone.0058751

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596291/
https://www.ncbi.nlm.nih.gov/pubmed/23516551
http://dx.doi.org/10.1371/journal.pone.0058751

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