Mitochondrial Biogenesis Drives a Vicious Cycle of Metabolic Insufficiency and Mitochondrial DNA Deletion Mutation Accumulation in Aged Rat Skeletal Muscle Fibers

Aged muscles possess dysfunctional fibers that contain intracellular expansions of somatically derived mitochondrial DNA deletion mutations. At high abundance, these mutations disrupt the expression of mitochondrially-encoded protein subunits of the electron transport chain resulting in aerobic resp...

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Detalles Bibliográficos
Autores principales: Herbst, Allen, Johnson, Chad J., Hynes, Kayla, McKenzie, Debbie, Aiken, Judd M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596334/
https://www.ncbi.nlm.nih.gov/pubmed/23516592
http://dx.doi.org/10.1371/journal.pone.0059006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596334/
https://www.ncbi.nlm.nih.gov/pubmed/23516592
http://dx.doi.org/10.1371/journal.pone.0059006

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