Kinetic and Structural Evidences on Human Prolidase Pathological Mutants Suggest Strategies for Enzyme Functional Rescue

Prolidase is the only human enzyme responsible for the digestion of iminodipeptides containing proline or hydroxyproline at their C-terminal end, being a key player in extracellular matrix remodeling. Prolidase deficiency (PD) is an intractable loss of function disease, characterized by mutations in...

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Detalles Bibliográficos
Autores principales: Besio, Roberta, Gioia, Roberta, Cossu, Federica, Monzani, Enrico, Nicolis, Stefania, Cucca, Lucia, Profumo, Antonella, Casella, Luigi, Tenni, Ruggero, Bolognesi, Martino, Rossi, Antonio, Forlino, Antonella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596340/
https://www.ncbi.nlm.nih.gov/pubmed/23516557
http://dx.doi.org/10.1371/journal.pone.0058792

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