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Lipoprotein metabolism in nonalcoholic fatty liver disease

Nonalcoholic fatty liver disease (NAFLD), an escalating health problem worldwide, covers a spectrum of pathologies characterized by fatty accumulation in hepatocytes in early stages, with potential progression to liver inflammation, fibrosis, and failure. A close, yet poorly understood link exists b...

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Detalles Bibliográficos
Autores principales: Jiang, Zhenghui Gordon, Robson, Simon C., Yao, Zemin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editorial Department of Journal of Biomedical Research 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596749/
https://www.ncbi.nlm.nih.gov/pubmed/23554788
http://dx.doi.org/10.7555/JBR.27.20120077
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author Jiang, Zhenghui Gordon
Robson, Simon C.
Yao, Zemin
author_facet Jiang, Zhenghui Gordon
Robson, Simon C.
Yao, Zemin
author_sort Jiang, Zhenghui Gordon
collection PubMed
description Nonalcoholic fatty liver disease (NAFLD), an escalating health problem worldwide, covers a spectrum of pathologies characterized by fatty accumulation in hepatocytes in early stages, with potential progression to liver inflammation, fibrosis, and failure. A close, yet poorly understood link exists between NAFLD and dyslipidemia, a constellation of abnormalities in plasma lipoproteins including triglyceride-rich very low density lipoproteins. Apolipoproteins are a group of primarily liver-derived proteins found in serum lipoproteins; they not only play an extracellular role in lipid transport between vital organs through circulation, but also play an important intracellular role in hepatic lipoprotein assembly and secretion. The liver functions as the central hub for lipoprotein metabolism, as it dictates lipoprotein production and to a significant extent modulates lipoprotein clearance. Lipoprotein metabolism is an integral component of hepatocellular lipid homeostasis and is implicated in the pathogenesis, potential diagnosis, and treatment of NAFLD.
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spelling pubmed-35967492013-04-02 Lipoprotein metabolism in nonalcoholic fatty liver disease Jiang, Zhenghui Gordon Robson, Simon C. Yao, Zemin J Biomed Res Invited Review Nonalcoholic fatty liver disease (NAFLD), an escalating health problem worldwide, covers a spectrum of pathologies characterized by fatty accumulation in hepatocytes in early stages, with potential progression to liver inflammation, fibrosis, and failure. A close, yet poorly understood link exists between NAFLD and dyslipidemia, a constellation of abnormalities in plasma lipoproteins including triglyceride-rich very low density lipoproteins. Apolipoproteins are a group of primarily liver-derived proteins found in serum lipoproteins; they not only play an extracellular role in lipid transport between vital organs through circulation, but also play an important intracellular role in hepatic lipoprotein assembly and secretion. The liver functions as the central hub for lipoprotein metabolism, as it dictates lipoprotein production and to a significant extent modulates lipoprotein clearance. Lipoprotein metabolism is an integral component of hepatocellular lipid homeostasis and is implicated in the pathogenesis, potential diagnosis, and treatment of NAFLD. Editorial Department of Journal of Biomedical Research 2013-01 2012-12-01 /pmc/articles/PMC3596749/ /pubmed/23554788 http://dx.doi.org/10.7555/JBR.27.20120077 Text en © 2013 by the Journal of Biomedical Research. All rights reserved. This work is licensed under a Creative Commons Attribution 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/
spellingShingle Invited Review
Jiang, Zhenghui Gordon
Robson, Simon C.
Yao, Zemin
Lipoprotein metabolism in nonalcoholic fatty liver disease
title Lipoprotein metabolism in nonalcoholic fatty liver disease
title_full Lipoprotein metabolism in nonalcoholic fatty liver disease
title_fullStr Lipoprotein metabolism in nonalcoholic fatty liver disease
title_full_unstemmed Lipoprotein metabolism in nonalcoholic fatty liver disease
title_short Lipoprotein metabolism in nonalcoholic fatty liver disease
title_sort lipoprotein metabolism in nonalcoholic fatty liver disease
topic Invited Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596749/
https://www.ncbi.nlm.nih.gov/pubmed/23554788
http://dx.doi.org/10.7555/JBR.27.20120077
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