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Lipoprotein metabolism in nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD), an escalating health problem worldwide, covers a spectrum of pathologies characterized by fatty accumulation in hepatocytes in early stages, with potential progression to liver inflammation, fibrosis, and failure. A close, yet poorly understood link exists b...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Editorial Department of Journal of Biomedical Research
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596749/ https://www.ncbi.nlm.nih.gov/pubmed/23554788 http://dx.doi.org/10.7555/JBR.27.20120077 |
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author | Jiang, Zhenghui Gordon Robson, Simon C. Yao, Zemin |
author_facet | Jiang, Zhenghui Gordon Robson, Simon C. Yao, Zemin |
author_sort | Jiang, Zhenghui Gordon |
collection | PubMed |
description | Nonalcoholic fatty liver disease (NAFLD), an escalating health problem worldwide, covers a spectrum of pathologies characterized by fatty accumulation in hepatocytes in early stages, with potential progression to liver inflammation, fibrosis, and failure. A close, yet poorly understood link exists between NAFLD and dyslipidemia, a constellation of abnormalities in plasma lipoproteins including triglyceride-rich very low density lipoproteins. Apolipoproteins are a group of primarily liver-derived proteins found in serum lipoproteins; they not only play an extracellular role in lipid transport between vital organs through circulation, but also play an important intracellular role in hepatic lipoprotein assembly and secretion. The liver functions as the central hub for lipoprotein metabolism, as it dictates lipoprotein production and to a significant extent modulates lipoprotein clearance. Lipoprotein metabolism is an integral component of hepatocellular lipid homeostasis and is implicated in the pathogenesis, potential diagnosis, and treatment of NAFLD. |
format | Online Article Text |
id | pubmed-3596749 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Editorial Department of Journal of Biomedical Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-35967492013-04-02 Lipoprotein metabolism in nonalcoholic fatty liver disease Jiang, Zhenghui Gordon Robson, Simon C. Yao, Zemin J Biomed Res Invited Review Nonalcoholic fatty liver disease (NAFLD), an escalating health problem worldwide, covers a spectrum of pathologies characterized by fatty accumulation in hepatocytes in early stages, with potential progression to liver inflammation, fibrosis, and failure. A close, yet poorly understood link exists between NAFLD and dyslipidemia, a constellation of abnormalities in plasma lipoproteins including triglyceride-rich very low density lipoproteins. Apolipoproteins are a group of primarily liver-derived proteins found in serum lipoproteins; they not only play an extracellular role in lipid transport between vital organs through circulation, but also play an important intracellular role in hepatic lipoprotein assembly and secretion. The liver functions as the central hub for lipoprotein metabolism, as it dictates lipoprotein production and to a significant extent modulates lipoprotein clearance. Lipoprotein metabolism is an integral component of hepatocellular lipid homeostasis and is implicated in the pathogenesis, potential diagnosis, and treatment of NAFLD. Editorial Department of Journal of Biomedical Research 2013-01 2012-12-01 /pmc/articles/PMC3596749/ /pubmed/23554788 http://dx.doi.org/10.7555/JBR.27.20120077 Text en © 2013 by the Journal of Biomedical Research. All rights reserved. This work is licensed under a Creative Commons Attribution 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/ |
spellingShingle | Invited Review Jiang, Zhenghui Gordon Robson, Simon C. Yao, Zemin Lipoprotein metabolism in nonalcoholic fatty liver disease |
title | Lipoprotein metabolism in nonalcoholic fatty liver disease |
title_full | Lipoprotein metabolism in nonalcoholic fatty liver disease |
title_fullStr | Lipoprotein metabolism in nonalcoholic fatty liver disease |
title_full_unstemmed | Lipoprotein metabolism in nonalcoholic fatty liver disease |
title_short | Lipoprotein metabolism in nonalcoholic fatty liver disease |
title_sort | lipoprotein metabolism in nonalcoholic fatty liver disease |
topic | Invited Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596749/ https://www.ncbi.nlm.nih.gov/pubmed/23554788 http://dx.doi.org/10.7555/JBR.27.20120077 |
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