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Iron deficiency and heart failure: diagnostic dilemmas and therapeutic perspectives

Iron is a micronutrient essential for cellular energy and metabolism, necessary for maintaining body homoeostasis. Iron deficiency is an important co-morbidity in patients with heart failure (HF). A major factor in the pathogenesis of anaemia, it is also a separate condition with serious clinical co...

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Autores principales: Jankowska, Ewa A., von Haehling, Stephan, Anker, Stefan D., Macdougall, Iain C., Ponikowski, Piotr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596759/
https://www.ncbi.nlm.nih.gov/pubmed/23100285
http://dx.doi.org/10.1093/eurheartj/ehs224
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author Jankowska, Ewa A.
von Haehling, Stephan
Anker, Stefan D.
Macdougall, Iain C.
Ponikowski, Piotr
author_facet Jankowska, Ewa A.
von Haehling, Stephan
Anker, Stefan D.
Macdougall, Iain C.
Ponikowski, Piotr
author_sort Jankowska, Ewa A.
collection PubMed
description Iron is a micronutrient essential for cellular energy and metabolism, necessary for maintaining body homoeostasis. Iron deficiency is an important co-morbidity in patients with heart failure (HF). A major factor in the pathogenesis of anaemia, it is also a separate condition with serious clinical consequences (e.g. impaired exercise capacity) and poor prognosis in HF patients. Experimental evidence suggests that iron therapy in iron-deficient animals may activate molecular pathways that can be cardio-protective. Clinical studies have demonstrated favourable effects of i.v. iron on the functional status, quality of life, and exercise capacity in HF patients. It is hypothesized that i.v. iron supplementation may become a novel therapy in HF patients with iron deficiency.
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spelling pubmed-35967592013-03-14 Iron deficiency and heart failure: diagnostic dilemmas and therapeutic perspectives Jankowska, Ewa A. von Haehling, Stephan Anker, Stefan D. Macdougall, Iain C. Ponikowski, Piotr Eur Heart J Review Iron is a micronutrient essential for cellular energy and metabolism, necessary for maintaining body homoeostasis. Iron deficiency is an important co-morbidity in patients with heart failure (HF). A major factor in the pathogenesis of anaemia, it is also a separate condition with serious clinical consequences (e.g. impaired exercise capacity) and poor prognosis in HF patients. Experimental evidence suggests that iron therapy in iron-deficient animals may activate molecular pathways that can be cardio-protective. Clinical studies have demonstrated favourable effects of i.v. iron on the functional status, quality of life, and exercise capacity in HF patients. It is hypothesized that i.v. iron supplementation may become a novel therapy in HF patients with iron deficiency. Oxford University Press 2013-03-14 2012-10-25 /pmc/articles/PMC3596759/ /pubmed/23100285 http://dx.doi.org/10.1093/eurheartj/ehs224 Text en © The Author 2012. Published by Oxford University Press on behalf of European Society of Cardiology. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial reuse, distribution, and reproduction in any medium, provided that the original authorship is properly and fully attributed; the Journal, Learned Society and Oxford University Press are attributed as the original place of publication with correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oup.com.
spellingShingle Review
Jankowska, Ewa A.
von Haehling, Stephan
Anker, Stefan D.
Macdougall, Iain C.
Ponikowski, Piotr
Iron deficiency and heart failure: diagnostic dilemmas and therapeutic perspectives
title Iron deficiency and heart failure: diagnostic dilemmas and therapeutic perspectives
title_full Iron deficiency and heart failure: diagnostic dilemmas and therapeutic perspectives
title_fullStr Iron deficiency and heart failure: diagnostic dilemmas and therapeutic perspectives
title_full_unstemmed Iron deficiency and heart failure: diagnostic dilemmas and therapeutic perspectives
title_short Iron deficiency and heart failure: diagnostic dilemmas and therapeutic perspectives
title_sort iron deficiency and heart failure: diagnostic dilemmas and therapeutic perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596759/
https://www.ncbi.nlm.nih.gov/pubmed/23100285
http://dx.doi.org/10.1093/eurheartj/ehs224
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