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Iron deficiency and heart failure: diagnostic dilemmas and therapeutic perspectives
Iron is a micronutrient essential for cellular energy and metabolism, necessary for maintaining body homoeostasis. Iron deficiency is an important co-morbidity in patients with heart failure (HF). A major factor in the pathogenesis of anaemia, it is also a separate condition with serious clinical co...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596759/ https://www.ncbi.nlm.nih.gov/pubmed/23100285 http://dx.doi.org/10.1093/eurheartj/ehs224 |
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author | Jankowska, Ewa A. von Haehling, Stephan Anker, Stefan D. Macdougall, Iain C. Ponikowski, Piotr |
author_facet | Jankowska, Ewa A. von Haehling, Stephan Anker, Stefan D. Macdougall, Iain C. Ponikowski, Piotr |
author_sort | Jankowska, Ewa A. |
collection | PubMed |
description | Iron is a micronutrient essential for cellular energy and metabolism, necessary for maintaining body homoeostasis. Iron deficiency is an important co-morbidity in patients with heart failure (HF). A major factor in the pathogenesis of anaemia, it is also a separate condition with serious clinical consequences (e.g. impaired exercise capacity) and poor prognosis in HF patients. Experimental evidence suggests that iron therapy in iron-deficient animals may activate molecular pathways that can be cardio-protective. Clinical studies have demonstrated favourable effects of i.v. iron on the functional status, quality of life, and exercise capacity in HF patients. It is hypothesized that i.v. iron supplementation may become a novel therapy in HF patients with iron deficiency. |
format | Online Article Text |
id | pubmed-3596759 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-35967592013-03-14 Iron deficiency and heart failure: diagnostic dilemmas and therapeutic perspectives Jankowska, Ewa A. von Haehling, Stephan Anker, Stefan D. Macdougall, Iain C. Ponikowski, Piotr Eur Heart J Review Iron is a micronutrient essential for cellular energy and metabolism, necessary for maintaining body homoeostasis. Iron deficiency is an important co-morbidity in patients with heart failure (HF). A major factor in the pathogenesis of anaemia, it is also a separate condition with serious clinical consequences (e.g. impaired exercise capacity) and poor prognosis in HF patients. Experimental evidence suggests that iron therapy in iron-deficient animals may activate molecular pathways that can be cardio-protective. Clinical studies have demonstrated favourable effects of i.v. iron on the functional status, quality of life, and exercise capacity in HF patients. It is hypothesized that i.v. iron supplementation may become a novel therapy in HF patients with iron deficiency. Oxford University Press 2013-03-14 2012-10-25 /pmc/articles/PMC3596759/ /pubmed/23100285 http://dx.doi.org/10.1093/eurheartj/ehs224 Text en © The Author 2012. Published by Oxford University Press on behalf of European Society of Cardiology. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial reuse, distribution, and reproduction in any medium, provided that the original authorship is properly and fully attributed; the Journal, Learned Society and Oxford University Press are attributed as the original place of publication with correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oup.com. |
spellingShingle | Review Jankowska, Ewa A. von Haehling, Stephan Anker, Stefan D. Macdougall, Iain C. Ponikowski, Piotr Iron deficiency and heart failure: diagnostic dilemmas and therapeutic perspectives |
title | Iron deficiency and heart failure: diagnostic dilemmas and therapeutic perspectives |
title_full | Iron deficiency and heart failure: diagnostic dilemmas and therapeutic perspectives |
title_fullStr | Iron deficiency and heart failure: diagnostic dilemmas and therapeutic perspectives |
title_full_unstemmed | Iron deficiency and heart failure: diagnostic dilemmas and therapeutic perspectives |
title_short | Iron deficiency and heart failure: diagnostic dilemmas and therapeutic perspectives |
title_sort | iron deficiency and heart failure: diagnostic dilemmas and therapeutic perspectives |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596759/ https://www.ncbi.nlm.nih.gov/pubmed/23100285 http://dx.doi.org/10.1093/eurheartj/ehs224 |
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