The huntingtin N17 domain is a multifunctional CRM1 and Ran-dependent nuclear and cilial export signal

The first 17 amino acids of Huntington’s disease (HD) protein, huntingtin, comprise an amphipathic alpha-helical domain that can target huntingtin to the endoplasmic reticulum (ER). N17 is phosphorylated at two serines, shown to be important for disease development in genetic mouse models, and shown...

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Detalles Bibliográficos
Autores principales: Maiuri, T., Woloshansky, T., Xia, J., Truant, R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596850/
https://www.ncbi.nlm.nih.gov/pubmed/23297360
http://dx.doi.org/10.1093/hmg/dds554

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596850/
https://www.ncbi.nlm.nih.gov/pubmed/23297360
http://dx.doi.org/10.1093/hmg/dds554

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